[BBC] Position for a Bioinformatician at GSK

[Jacques van Helden]

Begin forwarded message:

From: jean-louis.ruelle at gskbio.com
Date: 25 novembre 2008 16:16:27 GMT+01:00
Subject: Recrutement bioinfo

Job Purpose
==========
Within the Bioinformatics group in R&D, the bioinformaticians provide  
support and creative output in the DNA and protein sequence/structure  
aspects of vaccine design in all research projects. Bioinformatics has  
also taken the responsibility of statistical analysis of huge data  
sets coming from microarray experiments performed in various vaccine  
projects, in particular a novel class of oncology compounds, the  
therapeutic cancer vaccines. Activities in the latter field have  
substantially increased recently, and we are looking for an additional  
skilled person. You will join the vaccine headquarters located in  
Rixensart, Belgium, where 5 bioinformaticians are devoted to the  
bioinformatics support to the discovery and development of vaccines.

Responsibilities
============
The job involves performing statistical data analysis of microarray  
experiments, in collaboration with molecular biology.
This includes:
- Development of prognostic and predictive classifiers in cancer using  
gene expression microarray data
- Use of external datasets to validate and evaluate classifier  
performance
- Collaborate with molecular biology group to facilitate the migration  
of diagnostic, prognostic and predictive marker-basedprojects from  
discovery to development and manufacturing, as regulatory approved  
commercial products
- Interact with molecular biology group to establish and apply quality  
control pipeline to gene expression microarray data
- Technology watch and development of new bioinformatic tools for  
cancer tumor classification and data processing
- Share expertise and know-how
- Support molecular biology and CIP with sequence analysis and  
annotation of biomarkers using genome databases
- Maintaining and promoting contacts with external colleaguesand  
academic research.
- Reporting on progress and results to the research project teams.

Profile
=====
- You have a Ph-D in Life Sciences or Computer Sciences or equivalent.
- Proficiency in bioinformatics and statistics with good knowledge of  
sample classification methods using high dimensional data (background  
in machine learning is desirable)
- Familiarity with pre-processing of gene expression microarray data  
(QC, normalization, etc )
- Knowledge in R programming is highly desirable
- Knowledge of sequence analysis and annotation retrieval from genome  
databases will be advantageous
- You are willing to learn everyday, you are open, creative, you can  
work autonomously.
- You have excellent communication and organizational skills.
- You have an good knowledge of English (oral and written).

Contact and information:
===================
	Jean-Louis Ruelle <jean-louis.ruelle at gskbio.com>