[BBC] PhD sholarship: bioinformatics pipelines for genotype-to-phenotype experiments - 4 years

[Morris Swertz]

Dear colleages,

I have a PhD position available in genotype-to-phenotype bioinformatics pipelines that might be of interest to members of our Taverna community.
Could you please circulate within your respective institutions?

Thank you,
Morris
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4year PhD scholarship

Flexible bioinformatics pipelines for the integration of genotype-to-phenotype experiments
Where: Genetics department & Groningen Bioinformatics Center, University Medical Center Groningen, Netherlands
Apply: To m.a.swertz at rug.nl before November 6st, 2009
Start: Before December 31st, 2009

Summary:
Most (disease) phenotypes have a complex inheritance. Integrated 
analyses of (i) high-throughput sequencing, genotype, transcript, 
protein, metabolic and phenotypic/clinical profiling data, (ii) use of 
model organisms such as mouse and worm, and (iii) integration of 
background information from literature and public database show much 
potential to unravel these genome-to-phenotype trajectories.

This exciting project will (i) define minimal parameters, models, 
algorithms and tools for the efficient generation of (ii) flexible 
“cyber infrastructures” to pipeline far greater volumes of experimental, 
functional and network data on human and mouse than can be achieved 
using manual analysis (iii) to pinpoint genes and molecular networks 
underlying complex phenotypes at significantly increased accuracy and 
reduced effort. You will build on novel "model-driven strategies" to 
generate the necessary software efficiently (Swertz, Nature Reviews 
Genetics, 2007), minimal models and ontologies for integrated 
representation of all these types of data (e.g. http://www.xgap.org, 
http://www.ebi.ac.uk/EFO), and a suite of open source software for the 
integration of data and tools (e.g. http://www.molgenis.org).

The ideal candidate has an MSc in bioinformatics, computer science, 
molecular biology, computational biology, artificial intelligence or a 
related field, proven interest in biology and bioinformatics, a strong 
programming background and excellent English communication skills. This 
bursary grant is guaranteed for 4 years at approximate € 1500 euro/month 
with an evaluation after one year.

Find the complete vacancy at
http://www.rug.nl/biologie/onderzoek/onderzoekGroepen/bioinformatics/Internships/PhDVacancyG2Ppipelines.pdf

Organisation:
http://www.rug.nl/umcg/faculteit/disciplinegroepen/medischegenetica/
http://www.rug.nl/gbic

**