[BBC] Fwd: Inserm workshop: Interactomics, spring 2010

[Jacques van Helden]

Begin forwarded message:

Chers collègues,

Vous trouverez ci-dessous l'annonce de notre atelier INSERM. N'hesitez
pas à la diffuser autour de vous!

Merci encore pour votre participation à l'atelier.

Cordialement,
Christine Brun - Jérôme Reboul - Nicolas Thierry-Mieg


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Atelier de Formation Inserm 203

Interactomique: à l'intersection de la biologie et la bioinfomatique /
Interactomics: at the crossroads of biology and bioinformatics

Registration dealine: January 29, 2010
Info and registration forms:
http://www.rh.inserm.fr/INSERM/IntraRH/RHPublication.nsf/mDisplayMotsClefsWeb?OpenForm&arg1=17&arg2=#


Phase I • Critical assessment
March 30- April 1, 2010 • Saint-Raphaël • France

Aims:
Proteins rarely act alone: they often interact with other macromolecules
in order to accomplish their functions. Protein-protein interactions are
therefore critical to most biological processes. Systematic approaches
for identifying them have been developped over the years, such as yeast
two-hybrid or affinity purification-mass spectrometry. These methods
have enabled the mapping of complex interaction networks in various
model organisms, which are profoundly modifying our understanding of
cellular mechanisms by providing us with an integrated view of
biological processes. However, due to their complexity, such networks
can be intimidating and difficult to take advantage of by
hypothesis-driven experimental biologists. The main difficulties are
typically methodological and technical (for example knowledge and
application of bioinformatics tools), but also and more fundamentally
they stem from the changes in reasoning required by the systems biology
approach. Protein-protein interaction networks being a very rich but
neglected source of information, the workshop will present the main
strengths and challenges in producing and using this data. Indeed, a
better understanding of the processes, questions and solutions proposed
by labs that produce and analyze interactomics data should facilitate
its general use.

Audience:
Researchers, physicians, post-docs, technicians, engineers and students
interested in the interactome approach and the analysis of existing
protein-protein interaction data, in order to benefit to their own
research projects.

The topics addressed will include 1) identifying protein-protein
interactions: high-throughput methods, validation of results, quality
assessment; 2) protein-protein interaction databases: contents,
standards, direct submissions; 3) topological and functional analysis of
protein-protein interaction networks: methods and tools; 4) application
to biological questions: candidate genes, signaling, host-pathogen
interactions, development, evolution.

Confirmed speakers:
Javier De Las Rivas (Salamanca, Spain), Etienne Formstecher (Paris,
France), Anne-Claude Gavin (Heidelberg, Germany), Kristin Gunsalus (New
York, USA), Henning Hermjakob (Hinxton, UK), Carl Herrmann (Marseille,
France), Vincent Lotteau (Lyon, France), Fabio Piano (New York, USA),
Evelyne Goillot (Lyon, France), Jolanta Polanowska (Marseille, France),
Sylvie Ricard-Blum (Lyon, France), Benno Schwikowski (Paris, France),
Jacques van Helden (Bruxelles, Belgium), Marc Vidal (Boston, USA).


Phase II • Technical workshop
May 2010 • Marseille

Program:
Participants will learn to use existing tools for extracting functional
information from publicly available molecular interaction data. The
course is aimed at two subgroups of participants, depending on their
computer skills. The goal is to enable the participants to study their
own results in the light of previously known biomolecular interactions.
15 participants will be selected among the phase I participants.


Organizers: Christine Brun (TAGC, Marseille), Jérôme Reboul (CRCM,
Marseille), Nicolas Thierry-Mieg (TIMC-IMAG, Grenoble)