[BBC] [Gtpb] Fwd: ANNOUNCEMENT: HPND12 - "Hunting for Promoters" Bioinformatics Training Course

[Pedro Fernandes]

                      ANNOUNCEMENT

HPND12 -  Hunting for Promoters with NGS data

with Alexander Kel, Martin Enge and Chritian Zinser

Course description:

This course is set-up to review the basic principles of gene  
regulation, first of all, by prediction of promoters and distant  
enhancers and silencers and by analysis of structure of the gene  
regulatory regions and identification of binding sites for  
transcription factors. The most intriguing parts of genomes, still  
hiding from clear understanding, are the gene regulatory regions --  
promoters and enhancers. Analysis and prediction of the regulatory  
sites in the genome, which is now a hot topic as a result of the  
growth of the number of newly sequenced genomes, and the result of  
high throughput sequencing methodologies becoming commonplace. Also,  
the introduction of high throughput-sequencing based techniques for  
genome-wide epigenetic analysis such as ChIP-seq has revolutionized  
our ways for studying the gene regulatory mechanisms. of First of all,  
effective and robust methods for annotation of new genomes are  
urgently needed now.But also, recognition and analysis of these areas  
in the new and existing genomes becomes one of the most important  
parts of understanding the mechanisms of genome functioning. In this  
course, the attendees will learn several techniques of finding  
promoters and enhancers and the principles on which these methods are  
based. Through "hands on" exercises, several analytical tools will be  
displayed and the results citicized in the light of assessing their  
reliability and the possibilities that they open of assigning gene  
function based on automatic prediction. Also, the course will include  
an overview of the state of the art in lab techniques for studying  
gene regulation as well as a detailed account of data analysis for the  
more commonly used techniques such as ChIP-seq.

Objectives
The course will consist of lectures that lay out the conceptual  
framework as needed and and "hands on" exercises will provide the  
practical insight on the use of the methods, gradually, in order to  
produce skills that can be used with a relatively high degree of  
independence. Participants will know how to set-up some of the  
programs, and use publicly available servers for more complex  
analytical jobs, in an informed fashion, so that they fully understand  
the output generated and how its quality can be assessed. Participants  
will also learn the novel principles of organization of gene  
regulatory regions, which will help them to interpret their results of  
genomics and transcriptomics studies.

Target Audience:
The course is directed to researchers in biology, bioinformatics,  
biochemistry and medicine. Background knowledge in elementary  
bioinformatics is not absolutely necessary, but can be very useful.
Please note that the PathProt brainstorming event takes place on the  
week just before this course. You will need to register in PathProt  
separately, though. Please use its specific PathProt website

Course Pre-requisites:
Basic biochemistry. Elementary computing skills

Futher details, including application instructions available at
http://gtpb.igc.gulbenkian.pt/bicourses/HPND12

thank you for your interest

Pedro Fernandes


-- 

Pedro Fernandes
GTPB Coordinator
Instituto Gulbenkian de Ciência
Apartado 14
2781-901 OEIRAS
Tel +351 21 4407912
http://gtpb.igc.gulbenkian.pt

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