[BBC] [Gtpb] REMINDER, new deadline. Structural Modeling for Large Macromolecular Complexes - SMLMC14 in Oeiras, Portugal

[Pedro Fernandes]

                     GTPB Reminder

Applications are open for another Bioinformatics Training course:

SMLMC14
Structural Modeling for Large Macromolecular Complexes
with Joanna Kasprzak and Grzegorz Chojnowski

    IMPORTANT DATES for this Course
    Deadline for applications: May 20th 2014        < New deadline
    Latest notification of acceptance: May 17th 2014
    Course date: June 11th - June 13th 2014

For a reference about the use of the methodology:
http://dx.doi.org/10.1016/j.ymeth.2013.09.014

*Computational modeling of protein–RNA complex structures*
Irina Tuszynska, Dorota Matelska, Marcin Magnus, Grzegorz Chojnowski,  
Joanna M. Kasprzak, Lukasz P. Kozlowski, Stanislaw Dunin-Horkawicz,  
Janusz M. Bujnicki

Laboratory of Bioinformatics and Protein Engineering, International  
Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4,  
PL-02-109 Warsaw, Poland
Bioinformatics Laboratory, Institute of Molecular Biology and  
Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul.  
Umultowska 89, PL-61-614 Poznan, Poland

***********************************************************************

Course description
One of the major challenges in structural biology is to determine the   
   structures of macromolecular complexes and to understand their   
function and mechanism of action. However, structural characterisation  
  of macromolecular assemblies is very difficult. To begin addressing   
this problem, we have developed PyRy3D.
In a nutshell, PyRy3D employs a hybrid computational approach that     
incorporates spatial information from a variety of experimental   
methods into the modelling procedure to build low-resolution models of  
  large macromolecular complexes. The PyRy3D model building procedure   
   uses a Monte Carlo approach to sample the solutions-space. It uses   
   spatial restraints to define components interacting with each  
other,  and a simple scoring function is applied to pack them tightly  
into  contours of the entire complex (e.g. cryoEM density maps).

More details at
http://gtpb.igc.gulbenkian.pt/bicourses/SMLMC14/

Thank you for your interest!

Pedro Fernandes
GTPB Coordinator

-- 
Pedro Fernandes
Instituto Gulbenkian de Ciência
Apartado 14
2781-901 OEIRAS
PORTUGAL
Tel +351 21 4407912
http://gtpb.igc.gulbenkian.pt


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