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We have an open position for a PhD or PostDoc on the topic of Computational Cancer Biology / Bioinformatics! </p>
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<a href="http://recruitment2.tudelft.nl/vacatures/index.php?type=a&lang=en&id=526490">http://recruitment2.tudelft.nl/vacatures/index.php?type=a&lang=en&id=526490</a></p>
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<span style="font-size: 11pt; font-family: Arial; font-weight: 700; color: rgb(0, 166, 214); ">Postdoc or PhD in Bioinformatics</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: Arial; font-weight: 700; ">Department/faculty: </span><span style="font-size: 9pt; font-family: ArialMT; ">Electrical Engineering, Mathematics and Computer Science </span><span style="font-size: 9pt; font-family: Arial; font-weight: 700; ">Level: </span><span style="font-size: 9pt; font-family: ArialMT; ">Master
degree<br>
</span><span style="font-size: 9pt; font-family: Arial; font-weight: 700; ">Working hours: </span><span style="font-size: 9pt; font-family: ArialMT; ">38 hours per week<br>
</span><span style="font-size: 9pt; font-family: Arial; font-weight: 700; ">Contract: </span><span style="font-size: 9pt; font-family: ArialMT; ">3 years (4 for PhD)</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: Arial; font-weight: 700; ">Salary: </span><span style="font-size: 9pt; font-family: ArialMT; ">€2042 to €3755 per month gross</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="color: rgb(0, 166, 214); font-family: Arial; font-size: 11pt; font-weight: 700; ">Job description</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">Cancer is a complex disease caused by a myriad of changes in the DNA sequence. We are currently entering an era in which it is possible to determine the complete
sequence of a cancer genome and capture a nearcomplete DNA mutation profile. As a result, it is becoming clear that each individual tumour is unique. A key question in cancer research is thus: how can we resolve the molecular mechanisms of cancer if the mutation
profile is different for each tumour?</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">In this project, we address this challenge with scalespace theory, allowing us to redefine a common mutation without making prior assumptions on the scale
at which these mutations are apparent. This is important because a cancer gene can be disrupted by a single base pair change or a largescale deletion of a chromosome arm, two completely different (spatial) scales along the genome axis. By combining data across
all possible scales, and by defining structure in these data at the appropriate scale, statistical power to detect a common ‘mutation’, and thus cancer genes, is maximised.</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">Scalespace theory can also be used when scale is defined in terms of a functional distance, such as in gene interaction networks, rather than a base pair
distance. This allows us to define common mutation of function, such as signaling cascades (smallscale) or whole genetic pathways (largescale). In addition to revealing novel biomarkers for cancer, we envision this will provide invaluable insight into the
context in which cancer genes deregulate important cellular processes, thus revealing new avenues for personalised treatment strategies.</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 11pt; font-family: Arial; font-weight: 700; color: rgb(0, 166, 214); ">Requirements</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">We are looking for candidates who have demonstrated excellence in one of the following (or related) fields: bioinformatics, (bio)statistics, machine vision,
pattern recognition or computer science. Candidates should possess an MSc degree (PhD for a postdoc appointment) and are expected to be fluent in written and spoken English. Knowledge of molecular biology is an advantage. Candidates are expected to be interested
in working at the boundaries of several research domains (computer science, bioinformatics, molecular biology), and with people from several international institutes (e.g. Kluyver, NKI).</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 11pt; font-family: Arial; font-weight: 700; color: rgb(0, 166, 214); ">Conditions of employment</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">The successful PhD candidate will be employed fulltime by TU Delft for a fixed period of 4 years within which he or she is expected to write a dissertation
leading to a doctoral degree (PhD thesis). The starting salary for a PhD is €2062 gross per month increasing to a maximum of €2638 gross per month in the fourth year. The starting salary for a Postdoc is €3007.<br>
TU Delft offers an attractive benefits package, including a flexible work week, free highspeed Internet access from home (with a contract of two years or longer), and the option of assembling a customised compensation and benefits package (the 'IKA'). Salary
and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 11pt; font-family: Arial; font-weight: 700; color: rgb(0, 166, 214); ">Information and application</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">For more information about this position, please contact Dr. Jeroen de Ridder, phone: +31 (0)152783418, email: <a href="mailto:j.deridder@tudelft.nl">j.deridder@tudelft.nl</a>.
To apply, please email a detailed CV including contact details of references, a course list with grades and a letter of application in which you explain both your interest and the relevance of your skills and experience in the context of this research project.
Please email your application by 15 april 2013 to Mrs. W. M. Dicke, Hreemcs@<a href="http://tudelft.nl/">tudelft.nl</a>.</span></p>
<p style="background-color: rgb(255, 255, 255); "><span style="font-size: 9pt; font-family: ArialMT; ">When applying for this position, please refer to vacancy number EWI201307. </span></p>
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