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<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3"><b>PhD
/ Postdoc position on Evolutionary Cell Biology of the
Mitotic
Checkpoint.</b></font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">We
are looking for a motivated PhD student or postdoc with
experience in
evolutionary bioinformatics, and with affinity for
understanding the
role of protein networks in biological processes. The project
seeks
to derive functional insights into chromosome segregation from
the
study of protein co-evolution at the residue, motif, domain
and
protein level within the mitotic checkpoint signaling pathway.
Novel
and improved co-evolution studies are now possible thanks to
an
avalanche of new complete genomes. The project will encompass
development of new tools and continuous refinement of a
pipeline to
describe and detect co-evolution between proteins. Importantly
this
bioinformatic pipeline will be used for generating detailed
predictions on function and evolution of mitotic checkpoint
proteins.
As such, the candidate is expected to develop extensive
expertise on
chromosome segregation in general, and the mitotic checkpoint
in
particular, to push the limits on these <font size="3">p</font>redictions.</font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3"><b>Department
information</b></font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">The
lab of Geert Kops is part of the department of Medical
Oncology and
the department of Molecular Cancer Research at the UMC
Utrecht. These
departments are renowned for their fundamental and
translational
cancer research. The lab is located in the Stratenum building,
that
additionally houses various state-of-the-art facilities,
including
microscopy, proteomics, cell-screening, biochemistry and
next-generation sequencing. The Kops lab consist of 6 PhD
student, 3
postdocs and 4 technicians.</font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">The
lab of Berend Snel is part of the Institute for Biodynamics
and
Biocomplexity of the Faculty of Science. This institute aims
to
achieve a systems-level understanding of complex dynamic
processes
and their evolution through close interaction between
experimentation
and computational biology. The Snel group currently consists
of 4 PhD
students and 1 postdoc working on the evolution and function
of
different biological systems.</font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3"><b>How
to apply</b></font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">Please
send your CV, along with a cover letter outlining your
specific
qualifications for the preferred positions including contact
information for at least two references to Dr. Berend Snel,
<a class="moz-txt-link-abbreviated" href="mailto:B.Snel@uu.nl">B.Snel@uu.nl</a>.</font></font></p>
<p class="western" style="margin-bottom: 0in"><br>
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