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<font face="Calibri, sans-serif"><font size="3"><b><font size="3">P</font>hD
/ Postdoc position on Evolutionary Cell Biology of the Mitotic
Checkpoint.</b></font></font>
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<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">We are looking for a motivated PhD
student or postdoc with experience in evolutionary
bioinformatics, and with affinity for understanding the role
of protein networks in biological processes. The project
seeks to derive functional insights into chromosome
segregation from the study of protein co-evolution at the
residue, motif, domain and protein level within the mitotic
checkpoint signaling pathway. Novel and improved
co-evolution studies are now possible thanks to an avalanche
of new complete genomes. The project will encompass
development of new tools and continuous refinement of a
pipeline to describe and detect co-evolution between
proteins. Importantly this bioinformatic pipeline will be
used for generating detailed predictions on function and
evolution of mitotic checkpoint proteins. As such, the
candidate is expected to develop extensive expertise on
chromosome segregation in general, and the mitotic
checkpoint in particular, to push the limits on these <font
size="3">p</font>redictions.</font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3"><b>Department information</b></font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">The lab of Geert Kops is part of
the department of Medical Oncology and the department of
Molecular Cancer Research at the UMC Utrecht. These
departments are renowned for their fundamental and
translational cancer research. The lab is located in the
Stratenum building, that additionally houses various
state-of-the-art facilities, including microscopy,
proteomics, cell-screening, biochemistry and next-generation
sequencing. The Kops lab consist of 6 PhD student, 3
postdocs and 4 technicians.</font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">The lab of Berend Snel is part of
the Institute for Biodynamics and Biocomplexity of the
Faculty of Science. This institute aims to achieve a
systems-level understanding of complex dynamic processes and
their evolution through close interaction between
experimentation and computational biology. The Snel group
currently consists of 4 PhD students and 1 postdoc working
on the evolution and function of different biological
systems.</font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3"><b>How to apply</b></font></font></p>
<p class="western" style="margin-bottom: 0in"><font face="Calibri,
sans-serif"><font size="3">Please send your CV, along with a
cover letter outlining your specific qualifications for the
preferred positions including contact information for at
least two references to Dr. Berend Snel, <a
moz-do-not-send="true" class="moz-txt-link-abbreviated"
href="mailto:B.Snel@uu.nl">B.Snel@uu.nl</a>.</font></font></p>
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