<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 12 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Consolas;
panose-1:2 11 6 9 2 2 4 3 2 4;}
@font-face
{font-family:"Avenir Light";}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri","sans-serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
span.E-mailStijl17
{mso-style-type:personal-compose;
font-family:"Calibri","sans-serif";
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="NL" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:15.0pt;font-family:"Avenir Light""><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:17.0pt;font-family:"Avenir Light"">The effects of a mutation on protein structure and function<o:p></o:p></span></b></p>
<p class="MsoNormal"><i><span lang="EN-US" style="font-size:14.0pt">From NGS to mutation to structural interpretation</span></i><span lang="EN-US"><br>
<br>
</span><b><span lang="EN-US" style="font-size:17.0pt;font-family:"Avenir Light""><o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-family:"Avenir Light"">Date:
</span></b><span lang="EN-US" style="font-family:"Avenir Light"">June 3-4, 2014<br>
<b>Location: </b>CMBI, UMC Radboud,<b> </b>Nijmegen, the Netherlands<br>
<b>Course teachers: </b>Gert Vriend (CMBI), Hanka Venselaar (CMBI)<b> <br>
Course website & registration: </b></span><a href="http://swift.cmbi.ru.nl/gv/NGS"><span lang="EN-US" style="font-family:"Avenir Light";color:windowtext">http://swift.cmbi.ru.nl/gv/NGS</span></a><span lang="EN-US" style="font-family:"Avenir Light""> .<br>
<b>More information: </b></span><a href="mailto:Celia.vanGelder@radboudumc.nl"><span lang="EN-US" style="font-family:"Avenir Light";color:windowtext">Celia.vanGelder@radboudumc.nl</span></a><u><span lang="EN-US" style="font-family:"Avenir Light""><o:p></o:p></span></u></p>
<p class="MsoNormal"><a name="_GoBack"></a><b><span lang="EN-US" style="font-family:"Avenir Light""><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-family:"Avenir Light"">Course description</span></b><a name="h.gjdgxs"></a><span lang="EN-US"><br>
<br>
</span><span lang="EN-US" style="font-family:"Avenir Light"">Much research in NGS human DNA diagnostics labs is aimed at determining mutations causal for disease states. Many journals these days do no longer publish such studies unless accompanied from at least
a computational prediction of what the mutation does to the protein in terms of its structure and function.
<br>
<br>
This two day course aims at generating a level of understanding of the relation between protein structures, amino acids, and function. After the course the participants will be able to understand the output of compute servers that predict the structural and
functional effects of mutations in proteins with known structure (or for which the structure can be predicted with homology modelling). The users will also be able to perform elementary visual inspections of protein structures with and without mutations using
the YASARA software (that is free and runs on all computers). During the course we will work with the YASARA visualizer and the HOPE mutation effect prediction software (<a href="http://www.cmbi.ru.nl/hope/">http://www.cmbi.ru.nl/hope/</a> ). The educational
material and the seminars will be sufficiently general, though, to be applicable to other computational tools too.
<br>
<br>
<b>Target audience<br>
<br>
</b></span><span lang="EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Avenir Light"">The course is meant for novices in the protein structure field. As prior knowledge we expect that people have some minimal knowledge about amino acids, have an idea about how to operate
BLAST, and can use a browser.<br>
<br>
<b>Course programme<br>
<br>
</b></span><b><span lang="EN-US"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:18.0pt"><span lang="EN-US" style="font-family:"Avenir Light"">The course website, including the full course programme, can be found at
<b>: </b></span><a href="http://swift.cmbi.ru.nl/gv/NGS"><span lang="EN-US" style="font-family:"Avenir Light";color:windowtext">http://swift.cmbi.ru.nl/gv/NGS</span></a><span lang="EN-US" style="font-family:"Avenir Light""><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:Consolas">Dr. Celia W.G. van Gelder<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">Coordinator Education CMBI<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">Projectleader Education NBIC<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">tel. +31-(0)24-3666120<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">e-mail:
</span><span style="font-size:10.5pt;font-family:Consolas"><a href="mailto:C.vanGelder@umcn.nl"><span lang="EN-US">Celia.vanGelder@radboudumc.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">websites:
</span><span style="font-size:10.5pt;font-family:Consolas"><a href="http://www.cmbi.ru.nl/"><span lang="EN-US">www.cmbi.ru.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">,
</span><span style="font-size:10.5pt;font-family:Consolas"><a href="http://www.nbic.nl/"><span lang="EN-US">www.nbic.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">,
<a href="http://www.biosb.nl">www.biosb.nl</a> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">Postal address:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">CMBI 260<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas">Radboud University Nijmegen-Medical Centre /NCMLS PO Box 9101, 6500 HB Nijmegen The Netherlands<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:Consolas"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
</div>
<p style="font-size:13px;font-family:arial;">Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629.<br>
The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.<br>
</p>
</body>
</html>