<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 12 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Consolas;
panose-1:2 11 6 9 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin-top:0cm;
margin-right:0cm;
margin-bottom:10.0pt;
margin-left:0cm;
line-height:115%;
font-size:11.0pt;
font-family:"Calibri","sans-serif";
color:black;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
pre
{mso-style-priority:99;
mso-style-link:"HTML - vooraf opgemaakt Char";
margin:0cm;
margin-bottom:.0001pt;
font-size:10.0pt;
font-family:"Courier New";
color:black;}
span.HTML-voorafopgemaaktChar
{mso-style-name:"HTML - vooraf opgemaakt Char";
mso-style-priority:99;
mso-style-link:"HTML - vooraf opgemaakt";
font-family:Consolas;
color:black;}
span.E-mailStijl19
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:#1F497D;}
span.E-mailStijl20
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body bgcolor="white" lang="NL" link="blue" vlink="purple">
<div class="WordSection1">
<div>
<div>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-size:14.0pt;line-height:115%;color:windowtext">BioSB course on the systems-biology of individualized medicine:
<i>O2 for Personalized Medicine: from inspiration to aspiration<o:p></o:p></i></span></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:12.0pt;line-height:115%;color:windowtext"><br>
</span><b><span lang="EN-US" style="color:windowtext">Date: 28-30 January, 2015<br>
Location: Amsterdam<br>
Course Organizers: Barbara Bakker (</span></b><b><span lang="EN-US" style="color:windowtext">University Medical Centre Groningen (UMCG), Matteo Barberis, Gerard Muyzers and Hans V. Westerhoff (Centre for Integrative Systems Biology Amsterdam CISBA), in collaboration
with ISBE@NL<br>
Website: http://www.isbe-nl.nl/<br>
</span></b><span lang="EN-US" style="color:windowtext"><br>
On 28-30 January 2015 a course on the systems-biology of individualized medicine will be organized in Amsterdam. Human individuals are all a bit different, yet very much the same. We may all succumb to heart disease, arthritis or cancer, but there is no certainty
for any one of us; just probabilities. The probability that a medicine applied to a diseased individual works, is 30%. Einstein contended that probabilities only exist by virtue of ignorance. Systems Biology has the potential to reduce this ignorance. A recent
example is provided by the genome–wide human metabolic network, which has been reconstructed by systems biology on the basis of a thorough bioinformatics-aided integration of experimental data. By inserting an individual’s genome sequence plus lifestyle data
and by calibrating with functional genomics and physiological data, differences between individuals become understood. ‘Next generation systems biologists’ may soon create an individualized medicine with a 50 % hit rate for each therapy and with actual cures
for some of our multifactorial diseases. This course is for PhD students, postdocs and staff from academia and industry, aspiring to becoming these next generation systems biologists. It reviews recent progress and future potential in this endeavor, with some
in silico hands-on practicing.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="color:windowtext"><br>
Best regards<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="color:windowtext">Celia van Gelder<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><span lang="EN-US" style="color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">Dr. Celia W.G. van Gelder<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">Education Manager NBIC/BioSB<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">Coordinator Education CMBI<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;line-height:normal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">Programme Manager Learning DTL/ELIXIR-NL<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">tel. +31-(0)24-3666120<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">e-mail:
</span><span style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><a href="mailto:C.vanGelder@umcn.nl"><span lang="EN-US" style="color:windowtext">Celia.vanGelder@radboudumc.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">websites:
</span><span style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><a href="http://www.nbic.nl/"><span lang="EN-US" style="color:windowtext">www.nbic.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">,
</span><span style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><a href="www.biosb.nl"><span lang="EN-US" style="color:windowtext">www.biosb.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">,
</span><span style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><a href="http://www.cmbi.ru.nl/"><span lang="EN-US" style="color:windowtext">www.cmbi.ru.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">,
</span><span style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><a href="www.dtls.nl"><span lang="EN-US" style="color:windowtext">www.dtls.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">Postal address:<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">CMBI 260<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">Radboud University Nijmegen-Medical Centre<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">PO Box 9101<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:"Arial","sans-serif";color:windowtext">6500 HB Nijmegen The Netherlands<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span lang="EN-US" style="font-size:10.5pt;font-family:Consolas;color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;line-height:normal"><span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;line-height:normal"><span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:windowtext"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:windowtext"><o:p> </o:p></span></p>
</div>
<p style="font-size:13px;font-family:arial;">Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629.<br>
The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.<br>
</p>
</body>
</html>