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</o:shapelayout></xml><![endif]--></head><body lang=NL-BE link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal><span lang=EN-US>Dear All,<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><b><span lang=EN-US>Prof. Peter van Loo will give a seminar on Thursday, January 29 at 11 am: ‘Bioinformatics in cancer research’. </span></b><span lang=EN-US>(See abstract below)<b><o:p></o:p></b></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><span lang=EN-US>Please contact me if you would like to have a <b>meeting</b> with Prof. Peter van Loo in the afternoon.<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US>The lunch meeting is open to all PhD students, but lunch is only provided for students registered at the <b>Doctoral Schools</b>. Registration is still possible.<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><span lang=EN-US>With kind regards,<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><span lang=EN-US>Katrijn Vannerum<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>PhD<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>Project manager<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>N2N (From Nucleotides to Networks)<o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='font-size:9.0pt;color:black'>Multidisciplinary Research Partnership</span><span lang=EN-US style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='font-size:9.0pt;color:black'>Bioinformatics and Systems Biology</span><span lang=EN-US style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=FR style='font-size:9.0pt;color:black'>Ghent University</span><span lang=FR style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'><a href="http://www.nucleotides2networks.be/"><span lang=FR style='color:blue'>http://www.nucleotides2networks.be/</span></a></span><span lang=FR style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>twitter: @N2N_UGent</span><span style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'><a href="mailto:Katrijn.Vannerum@UGent.be"><span style='color:blue'>Katrijn.Vannerum@UGent.be</span></a></span><span style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>Technologiepark 927</span><span style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>9052 Gent, Belgium</span><span style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='color:black'>+32 (0)9 331 36 85</span><span style='color:black'><o:p></o:p></span></p><p class=MsoNormal><span style='color:black'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:black'> <o:p></o:p></span></p><table class=MsoTableGrid border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse;border:none'><tr><td width=238 valign=top style='width:178.8pt;padding:0cm 5.4pt 0cm 5.4pt'><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:#2F2B2A'><img border=0 width=224 height=120 id="Picture_x0020_3" src="cid:image005.png@01D02C24.94E42990"></span><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:#2F2B2A;mso-fareast-language:NL-BE'><o:p></o:p></span></p></td><td width=93 valign=top style='width:69.65pt;padding:0cm 5.4pt 0cm 5.4pt'><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:#2F2B2A;mso-fareast-language:NL-BE'><o:p> </o:p></span></p></td><td width=236 valign=top style='width:177.35pt;padding:0cm 5.4pt 0cm 5.4pt'><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:#2F2B2A'><img border=0 width=222 height=116 id="Picture_x0020_2" src="cid:image006.png@01D02C24.94E42990"></span><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:#2F2B2A;mso-fareast-language:NL-BE'><o:p></o:p></span></p></td></tr></table><p class=MsoNormal><span style='font-family:"Verdana","sans-serif";color:#2F2B2A'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:24.0pt;font-family:"Times New Roman","serif"'> </span></b><b><span lang=EN-US style='font-size:20.0pt;font-family:"Times New Roman","serif"'>“</span></b><b><span lang=EN style='font-size:20.0pt;font-family:"Times New Roman","serif"'>Bioinformatics in cancer research</span></b><b><span lang=EN-US style='font-size:20.0pt;font-family:"Times New Roman","serif"'>”<o:p></o:p></span></b></p><p class=MsoNormal><span lang=EN-US style='font-family:"Verdana","sans-serif";color:#2F2B2A'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN style='font-size:18.0pt;font-family:"Times New Roman","serif"'>Professor Peter van Loo <o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN style='font-size:14.0pt;font-family:"Times New Roman","serif"'>KU Leuven, Department of Human Genetics, Leuven, Belgium<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN style='font-size:14.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-US style='font-size:18.0pt;font-family:"Times New Roman","serif"'>January 29, 2014 (11:00)<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-US style='font-size:13.5pt;font-family:"Times New Roman","serif"'>Lunch meeting for Doctoral Schools students 12:00-14:00<o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:13.5pt;font-family:"Times New Roman","serif"'>Jozef Schell seminar room, Technologiepark 927 - 9052 Zwijnaarde<o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><a href="http://www.nucleotides2networks.be/node/232"><b><span style='font-size:13.5pt;font-family:"Times New Roman","serif"'>http://www.nucleotides2networks.be/node/232</span></b></a><span class=MsoHyperlink><b><span style='font-size:13.5pt;font-family:"Times New Roman","serif"'><o:p></o:p></span></b></span></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><a href="http://www.nucleotides2networks.be/events"><b><span style='font-size:13.5pt;font-family:"Times New Roman","serif"'>http://www.nucleotides2networks.be/events</span></b></a><b><span style='font-size:13.5pt;font-family:"Times New Roman","serif"'><o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:center'><b><span style='font-size:13.5pt;font-family:"Times New Roman","serif"'>Abstract<o:p></o:p></span></b></p><p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span lang=EN-GB style='font-family:"Times New Roman","serif";color:#2F2B2A'>Cancer evolves dynamically as clonal expansions supersede one another, driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We are developing algorithms to decipher this narrative from whole genome sequencing data and are applying them to several cancer types. We call such approaches “molecular archaeology of cancer”, as we are using genomics and bioinformatics algorithms to infer a tumour’s evolutionary history. I will discuss applications of our methods to breast cancer, allowing us to disentangle subclonal architecture from whole genome sequencing data, as well as time events such as chromosome duplications along a tumour’s lifetime. In addition, I will describe how extending these molecular archaeology approaches to multiple sampling studies allow enhanced and unique insights into cancer evolution, and I will illustrate that using genomics studies on prostate cancer metastases, where we are able to elucidate the patterns of metastatic spread in unprecedented detail.</span><span lang=EN-US style='font-family:"Times New Roman","serif";color:#2F2B2A'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p></div></body></html>