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<p><span lang="EN-US">Dear all,<o:p></o:p></span></p>
<p><span lang="EN-US"> On behalf of Adrian Liston, VIB KU Leuven:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">We kindly invite you to the seminar of Yuval Itan on July 1 at 11am (KUL, O&N4 auditorium):<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;line-height:14.25pt"><b><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">Finding a needle in a haystack: new approaches to identify disease-causing mutations in patients’
high-throughput sequencing data</span></b><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black"><o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;line-height:14.25pt"><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black"> <o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;line-height:14.25pt"><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">This seminar provides an insight into a new state-of-the-art gene-level metrics, tackling a crucial
question in medicine genomics: how to identify the relevance of a mutated gene to a disease? We identified for the first time the biological distance between all human genes, as well as the accumulated mutational damage and mutation significance cutoff for
each human gene. These gene-level approaches were shown to be particularly powerful for the identification of novel disease-causing genes in patients’ high-throughput data.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">The seminar is followed on July 2nd and 3rd by a practical tutorial on PC.</span><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:#1F497D"><o:p></o:p></span></p>
<p style="margin-bottom:12.0pt"><b><span lang="EN-US" style="font-size:16.0pt">Training 1: Disease causing mutations: filtering out disease-causing mutations
</span></b><span lang="EN-US"><o:p></o:p></span></p>
<p><b><span lang="EN-US" style="font-size:16.0pt">Training 2: The human connectome: picking candidate genes for disease from all-exome analysis
</span></b><o:p></o:p></p>
<p><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black"> <o:p></o:p></span></p>
<p><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">Trainer: Yuval Itan</span><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:#1F497D">,</span><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">
Rockefeller University </span><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:#1F497D"><o:p></o:p></span></p>
<p><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">Date : Training 1: 2th July, 9am, ends 1pm
<o:p></o:p></span></p>
<p><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">Training 2: 3th July, 9am, ends 1pm<o:p></o:p></span></p>
<p><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">Place : PC-LOKAAL ANATOMIE 2, ON2, 02.215 (KU Leuven)<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black"> <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt"><span lang="EN-US" style="font-size:11.5pt;font-family:"Helvetica","sans-serif";color:black">Host :
<a href="mailto:Adrian.Liston@vib.be" target="_blank"><span lang="NL-BE" style="color:windowtext;text-decoration:none">Adrian.Liston@vib.be</span></a></span><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black"><br>
<br>
Registration is free of charge, but places are limited, so register fast!</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black"><a href="https://docs.google.com/forms/d/1mYXe5dwh5WMPQn-hj_RRDxc5oEffR6fdfD0Nn1ZY4-U/edit?usp=sharing" target="_blank">https://docs.google.com/forms/d/1mYXe5dwh5WMPQn-hj_RRDxc5oEffR6fdfD0Nn1ZY4-U/edit?usp=sharing</a></span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black"> </span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black">Best regards</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black">Alex</span><o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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