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<!--StartFragment--><p class="MsoNormal" align="center" style="text-align:center"><b class=""><span style="font-size:16.0pt;mso-bidi-font-size:12.0pt;font-family:
Arial" class="">Computational cancer biology for precision medicine<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="text-align:justify;line-height:115%"><span style="font-size:10.0pt;line-height:115%;font-family:Arial" class=""> </span></p><p class="MsoNormal" style="text-align:justify;line-height:115%"><b class=""><span style="font-family:Arial" class="">Project
outline<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="text-align:justify;line-height:115%"><span style="font-family:Arial" class="">For an ambitious joint project between the
Netherlands Cancer Institute (NKI, Amsterdam, The Netherlands) and Glaxo Smith
Kline (Philadelphia, USA) we invite excellent and ambitious postdocs with
expertise in computational biology to apply. It is the goal of this
international team to study BET and EZH2 inhibitors. More specifically, we will
explore the molecular responses to these inhibitors, identify and understand
additional mechanisms of acquired and intrinsic resistance and identify markers
of sensitivity and resistance to these inhibitors. We will employ public and
proprietary data derived from model systems as well as patient data. In
addition to chemical profiling data, these data include gene expression, copy
number and ChIP-sequencing profiles as well as mutation data. The expected
duration of the initial phase of the project is 2 years. The computational
biologists will collaborate closely with experimentalists, and there will be
ample opportunity to validate hypotheses generated through computational
analyses.<o:p class=""></o:p></span></p><p class="MsoNormal" style="line-height:115%"><span style="font-family:Arial" class=""> </span></p><p class="MsoNormal" style="line-height:115%"><b class=""><span style="font-family:Arial" class="">Requirements<o:p class=""></o:p></span></b></p>
<ul style="margin-top:0cm" type="disc" class="">
<li class="MsoNormal" style="line-height:115%;mso-list:l0 level1 lfo1"><span style="font-family:Arial" class="">Degree in bioinformatics, physics, engineering,
computer science or mathematics <b class=""><o:p class=""></o:p></b></span></li>
<li class="MsoNormal" style="line-height:115%;mso-list:l0 level1 lfo1"><span style="font-family:Arial" class="">A strong cancer biology interest and/or
background <b class=""><o:p class=""></o:p></b></span></li>
<li class="MsoNormal" style="line-height:115%;mso-list:l0 level1 lfo1"><span style="font-family:Arial" class="">Proficiency in programming languages such as R, Python,
Perl.<b class=""><o:p class=""></o:p></b></span></li>
</ul><p class="MsoNormal" style="margin-left:36.0pt;line-height:115%"><b class=""><span style="font-family:Arial" class=""> </span></b></p><p class="MsoNormal" style="line-height:115%"><b class=""><span style="font-family:Arial" class="">Contact details<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="line-height:115%"><span style="font-family:Arial" class="">Please
contact Lodewyk Wessels (phone +31 20 512 7987, e-mail: </span><a href="mailto:l.wessels@nki.nl" class=""><span style="font-family:Arial;color:windowtext;
text-decoration:none;text-underline:none" class="">l.wessels@nki.nl</span></a>)<span style="font-family:Arial" class=""> or Mike McCabe (e-mail: <a href="mailto:michael.t.mccabe@gsk.com" class="">michael.t.mccabe@gsk.com</a>).
When applying, please ensure you include a CV, list of publications and the
names and addresses of at least two persons that can be approached as
references. Also see <a href="http://ccb.nki.nl/open-positions/" class="">http://ccb.nki.nl/open-positions/</a> for further information.<o:p class=""></o:p></span></p><p class="MsoNormal" style="line-height:115%"><span style="font-family:Arial" class=""> </span></p><p class="MsoNormal" style="line-height:115%"><b class=""><span style="font-family:Arial" class="">Closing date<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="line-height:115%"><span style="font-family:Arial" class="">15
November 2016<o:p class=""></o:p></span></p>
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