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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">BioSB Course Discovering Systems Biology Principles, 23-27 November 2015, Amsterdam<o:p></o:p></span></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">Website:
</span></b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif""><a href="http://biosb.nl/education/course-portfolio-2/course-discovering-systems-biology-principles/"><span style="color:windowtext">http://biosb.nl/education/course-portfolio-2/course-discovering-systems-biology-principles/</span></a>
<b><br>
Coordinators: </b></span><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">Frank Bruggeman (VU), Celia van Gelder (BioSB,
</span><span style="font-family:"Leelawadee","sans-serif""><a href="mailto:celia.van.gelder@biosb.nl"><span lang="EN-US" style="color:windowtext">celia.van.gelder@biosb.nl</span></a></span><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">)<b><br>
Registration:</b> <a href="http://biosb.nl/education/course-portfolio-2/course-discovering-systems-biology-principles/enrollment-dicovering-systems-biology-principles-course/">
<span style="color:windowtext">http://biosb.nl/education/course-portfolio-2/course-discovering-systems-biology-principles/enrollment-dicovering-systems-biology-principles-course/</span></a> .<b>Please not that this course is free of charge for PhDs who are
or will become a member of the BioSB research school, and with a reduced fee for other researchers who are or will become a member of BioSB</b>. More information about the BioSB membership can be found here:
<a href="http://biosb.nl/about/members/biosb-membership-information/"><span style="color:windowtext">http://biosb.nl/about/members/biosb-membership-information/</span></a> .<br>
<br>
<b>Course description</b><br>
A large part of systems biology is concerned with studying how the molecular networks inside living cells function. What they do. How their molecular interactions, including feedback circuitry, give rise to cellular properties, such as sensing, adaptation,
division and death, that transcend those of single molecules. This includes figuring out how gene mutations, causing changes in proteins, cause networks, and their cellular hosts, to malfunction. In order to do this, systems biology focusses on the dynamics
of molecular networks, using quantitative experiments and mathematical modeling. Mathematical models help systems biologists to figure out: i. how molecular properties relate to the functional, systemic properties of molecular networks, and ii. how molecular
networks assist in the survival and functioning of cells.<br>
This 1-week course serves as an introduction to mathematical modeling as it is used in systems biology.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">Course Programme<br>
</span></b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">We start from physical and chemical principles of molecules, cells and reactions. Next, you will learn how you can relate the changes in the concentrations of molecules over time to
the activity of reactions and the underlying molecular properties. You will be introduced to enzyme kinetics and the dynamics of small enzyme systems, in metabolism and signal transduction. We also briefly deal with models of genetic circuits. We will illustrate
a number of unexpected, functional properties of molecular networks that can be studied with simple mathematical models. You will make and analyse models yourself, on paper and with software. We will close the week with a short overview of some more advanced
topics, to introduce you to approaches and concepts that you will often hear about in systems biology.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">The course material concerns a syllabus (with exercises and answers), handouts, and computer exercises. At the end
of this 1-week course, you will have a good understanding how mathematical models are made, what biology they require and how you can use them in systems-biology research.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">Target audience<br>
</span></b><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">This course does not require any introductory reading or courses, it should be accessible to students with diverse backgrounds.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt"><span lang="EN-US" style="font-family:"Leelawadee","sans-serif""><br>
<b>BioSB Education Programme</b><br>
This course is part of the Education Programme of BioSB, the Netherlands Bioinformatics and Systems Biology Research School, which offers training and education in bioinformatics and systems biology. More information about BioSB can be found at
</span><span style="font-family:"Leelawadee","sans-serif""><a href="http://www.biosb.nl/"><span lang="EN-US" style="color:windowtext">www.biosb.nl</span></a></span><span lang="EN-US" style="font-family:"Leelawadee","sans-serif""> or via
</span><span style="font-family:"Leelawadee","sans-serif""><a href="mailto:education@biosb.nl"><span lang="EN-US" style="color:windowtext">education@biosb.nl</span></a></span><span lang="EN-US" style="font-family:"Leelawadee","sans-serif"">.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Leelawadee","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Leelawadee","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">Dr. Celia W.G. van Gelder<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">Education Manager BioSB<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">Coordinator Education CMBI<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">Programme Manager Learning DTL/ELIXIR-NL<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">tel. +31613375327<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">e-mail:
</span><span style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><a href="mailto:Celia.vanGelder@radboudumc.nl"><span lang="EN-US" style="color:windowtext">Celia.vanGelder@radboudumc.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">websites:
</span><span style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><a href="http://www.nbic.nl/"><span lang="EN-US" style="color:windowtext">www.nbic.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">,
</span><span style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><a href="www.biosb.nl"><span lang="EN-US" style="color:windowtext">www.biosb.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">,
</span><span style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><a href="http://www.cmbi.ru.nl/"><span lang="EN-US" style="color:windowtext">www.cmbi.ru.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">,
</span><span style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><a href="www.dtls.nl"><span lang="EN-US" style="color:windowtext">www.dtls.nl</span></a></span><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">Postal address:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">CMBI 260<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">Radboud University Nijmegen-Medical Centre<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">PO Box 9101<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif"">6500 HB Nijmegen The Netherlands<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.5pt;font-family:"Leelawadee","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Leelawadee","sans-serif""><o:p> </o:p></span></p>
</div>
<p style="font-size:13px;font-family:arial;">Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629.<br>
The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.<br>
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