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<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:24.0pt;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#434649">Drug discovery data scientist<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:24.0pt;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#434649">Key words: data sciences, computational biology, bioinformatics, drug discovery<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:24.0pt;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#434649">Permanent position at Janssen in Beerse<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:24.0pt;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#434649"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:24.0pt;background:white;vertical-align:baseline">
<u><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#434649">Context<o:p></o:p></span></u></p>
<p class="MsoNormal" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">Within the Discovery Sciences group, which provides advanced technology support to drug discovery projects in Janssen, the Computational Sciences department is responsible
for comprehensive analyses of high-dimensional datasets. The position will be opened on the Beerse campus, which is the largest R&D center for small molecules within the entire Janssen group, investing over 1 billion euros each year in R&D.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">Activities cover the integration of information from the broadest possible spectrum of datasources (chemical structure, microscopy images and omics, …) to comprehensively
infer biological activities of millions of chemical compounds, and to apply these predictions to inform projects. In addition, the team designs and supports the execution of the generation of high-dimensional datasets (from cytometry or various sequencing
approaches) from patient-derived material. The team is also responsible for the use of these data for the identification of potential mechanisms of disease and targets of intervention and the subpopulations of patients these mechanisms apply to.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;background:white;vertical-align:baseline">
<u><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">Job description<o:p></o:p></span></u></p>
<p class="MsoNormal" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">In the context of the latter task, the department is opening a permanent position for a drug discovery data scientist, who will focus on the analysis and interpretation
of high-dimensional datasets to identify interventional strategies for neurological, cardiovascular and metabolic, infectious, immunological or oncological diseases. The candidate will be responsible for<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpFirst" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:36.0pt;margin-bottom:.0001pt;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;text-indent:-18.0pt;line-height:150%;mso-list:l0 level1 lfo1;background:white;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;line-height:150%;font-family:Symbol;color:#434649"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">the translation of questions of disease experts in the therapeutic areas and wet lab colleagues, to a quantitative analysis formulation<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:36.0pt;margin-bottom:.0001pt;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;text-indent:-18.0pt;line-height:150%;mso-list:l0 level1 lfo1;background:white;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;line-height:150%;font-family:Symbol;color:#434649"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">the design and execution of targeted analysis approaches to link processed molecular and cellular data at scale to pathophysiological
processes or clinical outcome, to produce actionable conclusions and to inform decision making<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:36.0pt;margin-bottom:.0001pt;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;text-indent:-18.0pt;line-height:150%;mso-list:l0 level1 lfo1;background:white;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;line-height:150%;font-family:Symbol;color:#434649"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">the development and internalization of rigorous state-of-the-art approaches for integrative data analysis, and build-out and leveraging
of collaborations with leading academic and industrial scientific teams in life, computational and data sciences<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:36.0pt;margin-bottom:.0001pt;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;text-indent:-18.0pt;line-height:150%;mso-list:l0 level1 lfo1;background:white;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;line-height:150%;font-family:Symbol;color:#434649"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649">work with informatics and statistics colleagues to offer the resulting analysis and visualization solutions to the project teams<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:36.0pt;margin-bottom:.0001pt;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;text-indent:-18.0pt;line-height:150%;mso-list:l0 level1 lfo1;background:white;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;line-height:150%;font-family:Symbol;color:#434649"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#333333">contributing to the scientific weight of the department by authoring peer-reviewed papers and presenting at relevant conferences</span><span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif";color:#434649"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:12.0pt;margin-right:0cm;margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:200%;background:white;vertical-align:baseline">
<u><span style="font-size:10.0pt;line-height:200%;font-family:"Arial","sans-serif";color:#434649">Qualifications and skills<o:p></o:p></span></u></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoNormal" style="color:black;margin-bottom:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif"">PhD in Computational Biology or any related quantitative field with direct exposure to multidisciplinary biology or clinical context with ideally a few years of post-doctoral experience
in an academic or industrial setting<o:p></o:p></span></li><li class="MsoNormal" style="color:black;margin-bottom:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif"">demonstrated experience with linking high-dimensional molecular data, to phenotypic or clinical outcomes in constellations that led to hypothesis driven experimental or clinical
follow-up<o:p></o:p></span></li><li class="MsoNormal" style="color:black;margin-bottom:0cm;margin-bottom:.0001pt;text-align:justify;text-justify:inter-ideograph;line-height:150%;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;line-height:150%;font-family:"Arial","sans-serif"">advanced programming and scripting skills that enable the development of functional prototypes
</span><o:p></o:p></li><li class="MsoNormal" style="color:black;margin-bottom:0cm;margin-bottom:.0001pt;mso-list:l0 level1 lfo1">
excellent communication, reporting and team interaction skills, self-motivation, proactivity and the ability to work independently<o:p></o:p></li></ul>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">If you are interested, please reply with the appropriate documentation to
<i>hceulema – at – its – dot – jnj – dot – com.</i><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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