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<!--StartFragment--><p class="MsoNormal"><o:p class=""> </o:p></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;mso-bidi-font-family:Calibri" class="">Janssen
Discovery Sciences is a center of excellence focused on small-molecule drug
discovery at Janssed collaborators, perform cutting-edge research from target
& lead discovery through pre-clinical safety assessment to discover and
develop transformational medicines. Every day we use our deep scientific
expertise in drug discovery and development and our integrated suite of enabling
technologies, platforms and tools to advance the research portfolio of
Janssen’s five Therapeutic Areas: Cardiovascular & Metabolism, Immunology,
Infectious Diseases & Vaccines, Neuroscience and Oncology.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;mso-bidi-font-family:Calibri" class="">Within
Discovery Sciences, the department of Computational Sciences provides expertise
in computational/systems biology and big data analytics to support all aspects
of drug discovery and development. The team provides a variety of complementary
computational methodologies to extract meaningful and actionable information
from biomedical data to facilitate the identification and validation of new
targets in partnership with disease area experts in the therapeutic area
discovery groups. The team is heavily engaged in deploying bioinformatics,
machine learning and cutting-edge computational modeling and simulations
techniques to advance our understanding of disease. The in silico activities
are complemented and experimentally validated by wet lab capabilities within
the team, utilizing stem cell, molecular genetics, gene editing, next
generation sequencing and a variety of ‘-omics’ technologies<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;mso-bidi-font-family:Calibri" class="">We
are looking for an enthusiastic candidate to join the European Computational
Sciences team. The successful candidate will have a broad bioinformatics
experience with a good working knowledge of genetics / pathway biology and deep
scientific expertise in a number of disciplines including high-dimensional
omics technologies and data analysis, methodologies for drug discovery and
reverse translation coupled with the ability to work collaboratively with
internal and external partners. Whereas the position will be based in
Beerse (Belgium), it will support global teams in the different therapeutic
areas and its Disease Area Strongholds. Furthermore, as the immune system plays
a pivotal role in the progression of many diseases, we are searching for a
candidate with a background in immunology.<o:p class=""></o:p></span></p><p class="MsoNormal"><b class=""><span style="font-size:14.0pt;mso-ascii-font-family:Cambria;mso-hansi-font-family:
Cambria;mso-bidi-font-family:Cambria;color:#365F91" class="">Description of the function</span></b><span style="font-size:14.0pt;mso-ascii-font-family:Cambria;mso-hansi-font-family:
Cambria;mso-bidi-font-family:Cambria;color:#365F91" class=""><o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Work
closely with therapeutic area teams to understand where bioinformatics
approaches can best impact their scientific and technical challenges.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Steer
application of bioinformatics/genomics to benefit projects in therapeutic area
projects.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Work
collaboratively with wet lab, IT and statistical specialists to deliver
processes, tools and techniques to solve scientific problems.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Application
of a wide range of genomic technologies (RNAseq, WES, WGS) to target
identification, validation and biomarker discovery.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Development
and application of approaches combining multi-omic data sets (including
next-generation-sequencing) with phenotypic annotation to reveal actionable
insights surrounding complex biological problems.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Written
and verbal communication of study results to project teams, including proposals
for further experiments to validate key findings.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Build
and steer further development of small prototype tools for bench scientists to
access and visualize project data.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Play a
key role in the interactions with other omics experts in functional areas such
as Toxicology and Quantitative Sciences.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Collaborate
with industry and academia, and exploit external resources, to find the most
effective solutions to complex biological problems.<o:p class=""></o:p></span></p><p class="MsoNormal"><b class=""><span style="font-size:14.0pt;mso-ascii-font-family:Cambria;mso-hansi-font-family:
Cambria;mso-bidi-font-family:Cambria;color:#365F91" class="">Qualifications </span></b><span style="font-size:14.0pt;mso-ascii-font-family:Cambria;mso-hansi-font-family:
Cambria;mso-bidi-font-family:Cambria;color:#365F91" class=""><o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• PhD in
bioinformatics, biostatistics, computational biology or similar. Alternately, a
PhD in molecular biology, immunology, etc. combined with a very strong record
of high-throughput data analysis, supported by publication in this area.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Post-doctoral
experience as well as exposure to wet lab activities in an academic or
industrial setting is a plus.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Ability
to analyze and interpret complex omics datasets (e.g. microarrays,
next-generation sequencing, flow cytometry, mass spectrometry proteomics,
etc.).<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Proficiency
in appropriate programming languages and software (e.g., R /Python/Perl/
Spotfire) and data management.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Strong
written and oral presentation capabilities, with a convincing record of
peer-reviewed publications and presentations at scientific conferences. Ability
to clearly articulate scientific and operational concepts of biomarker research
across functions, levels, and disciplines.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• High
intrinsic motivation in combination with strong scientific curiosity and a high
level of autonomy.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Strong
interpersonal skills and ability to work productively in a highly dynamic
environment.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Strong
team orientation, highly collaborative and results-oriented.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Good
planning, prioritization, problem solving, and organizational skills.<o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri;
mso-bidi-font-family:Calibri" class="">• Knowledge
and understanding of the regulatory, legal and operational requirements of
sample collection and data handling for omics analyses in clinical studies is a
plus. <o:p class=""></o:p></span></p><p class="MsoNormal"><o:p class=""> </o:p></p>
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