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<p class="MsoNormal"><br>
<span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US">Dear all,<br>
</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US"><br>
We are looking for a PhD candidate in bioinformatics at the
Delft Bioinformatics Lab at TU Delft, The Netherlands, to work
on a project looking to develop </span><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US">rapid diagnosis of drug resistant and mixed TB
infections.</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US"><br>
</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US">Project and application details below.<br>
</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US"><br>
</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US">best,<br>
Thomas<br>
</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US"><br>
</span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:15.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB"><br>
PhD-position in Computational
Microbiology<o:p></o:p></span></b></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB">Title<br>
</span></b><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:
EN-US">Rapid diagnosis of drug resistant TB infections</span><i
style="mso-bidi-font-style:normal"><span
style="font-size:11.0pt;
mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB"><o:p></o:p></span></i></p>
<p class="MsoNormal"><span
style="font-size:5.0pt;mso-bidi-font-family:
Arial;mso-ansi-language:EN-GB" lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB">Project
leader<o:p></o:p></span></b></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:
Arial;mso-ansi-language:EN-GB" lang="EN-GB">Thomas Abeel<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:
Arial;mso-ansi-language:EN-GB" lang="EN-GB">Delft Bioinformatics
Lab – Pattern Recognition
and Bioinformatics – Department of Intelligent Systems<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:
Arial;mso-ansi-language:EN-GB" lang="EN-GB">Faculty of EEMCS,
Delft University of Technology
(TU Delft)<b style="mso-bidi-font-weight:normal"><br
style="mso-special-character:
line-break">
<!--[if !supportLineBreakNewLine]--><br
style="mso-special-character:line-break">
<!--[endif]--></b></span><span
style="font-size:5.0pt;mso-bidi-font-family:
Arial;mso-ansi-language:EN-GB" lang="EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB">Job
description<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;color:black;mso-themecolor:text1;mso-ansi-language:EN-GB"
lang="EN-GB">Despite treatment options, TB is killing 1.5
million people each year, the vast majority in developing
nations. Current
diagnostics often take several weeks or months, which is too
long to save the
lives of the patients or to prevent further transmission. This
project
collaborates with Dr. Pym of the K-RITH research institute in
Durban
South-Africa to develop an innovative rapid diagnostic that
accurately
identifies currently undiagnosable TB infections, i.e. mixed and
drug resistant
infections. This will be done by computationally identifying
markers that are
indicative of these infections in genomic data which are then
used to design
the diagnostic using existing sequencing technology.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span
style="font-size:5.0pt;mso-bidi-font-family:Arial;color:black;mso-themecolor:text1;mso-ansi-language:EN-GB"
lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB">Your
objectives in this project are to identify novel drug-resistance
conferring
mutations, to create a predictive model for drug resistance and
mixed
infections in TB and to explore the options to turn these
insights into a
prototype point-of-care molecular diagnostic. We have a
collection of
sequencing and meta-data from >8000 diverse TB strains. We
now have the
unique opportunity to leverage these data to make a global
societal impact. You
will integrate public and private data sets to associate
mutations with
phenotypes, such as drug resistance, with state-of-the-art
computational
approaches.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span
style="font-size:5.0pt;mso-bidi-font-family:Arial;color:black;mso-themecolor:text1;mso-ansi-language:EN-GB"
lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB">Requirements<o:p></o:p></span></b></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-bidi-font-family:
Arial;mso-ansi-language:EN-GB" lang="EN-GB">The ideal candidate
has an Msc degree in
bioinformatics or alternatively a degree in computer science or
(micro-)biology
with strong affinity or experience in the complementary field. </span><span
style="font-size:11.0pt;mso-fareast-font-family:"Times New
Roman";
mso-bidi-font-family:"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:
NL" lang="EN-GB">He/she must be able to work effectively in a
multidisciplinary team. The
candidate shares our view that communication skills are
important, as is the
ability to interact with peers, students and technical staff. </span><i
style="mso-bidi-font-style:normal"><span
style="font-size:11.0pt;
mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB"><o:p></o:p></span></i></p>
<p class="MsoListParagraphCxSpFirst"
style="text-indent:-.25in;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span
style="mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri;
mso-ansi-language:EN-GB" lang="EN-GB"><span
style="mso-list:Ignore">-<span style="font:7.0pt "Times
New Roman"">
</span></span></span><!--[endif]--><span
style="mso-ascii-font-family:
Calibri;mso-ascii-theme-font:minor-latin;mso-hansi-font-family:Calibri;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-ansi-language:
EN-GB" lang="EN-GB">Programming, algorithm development and
scripting experience are
desirable<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle"
style="text-indent:-.25in;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span
style="mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri;
mso-ansi-language:EN-GB" lang="EN-GB"><span
style="mso-list:Ignore">-<span style="font:7.0pt "Times
New Roman"">
</span></span></span><!--[endif]--><span
style="mso-ascii-font-family:
Calibri;mso-ascii-theme-font:minor-latin;mso-hansi-font-family:Calibri;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-ansi-language:
EN-GB" lang="EN-GB">Wet-lab experience is a plus<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast"
style="text-indent:-.25in;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span
style="mso-fareast-font-family:Calibri;mso-bidi-font-family:Calibri;
mso-ansi-language:EN-GB" lang="EN-GB"><span
style="mso-list:Ignore">-<span style="font:7.0pt "Times
New Roman"">
</span></span></span><!--[endif]--><span
style="mso-ascii-font-family:
Calibri;mso-ascii-theme-font:minor-latin;mso-hansi-font-family:Calibri;
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-ansi-language:
EN-GB" lang="EN-GB">Experience in microbial genomics is a plus<o:p></o:p></span></p>
<p class="MsoNormal"><i style="mso-bidi-font-style:normal"><span
style="font-size:5.0pt;mso-bidi-font-family:Arial;mso-ansi-language:EN-GB"
lang="EN-GB"><o:p> </o:p></span></i></p>
<p class="MsoNormal" style="tab-stops:center 3.15in"><strong><span
style="font-size:11.0pt;font-family:"Calibri","sans-serif";mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;
mso-ansi-language:EN-GB" lang="EN-GB">Information and
application<o:p></o:p></span></strong></p>
<p class="MsoNormal" style="tab-stops:center 3.15in"><span
style="font-size:11.0pt;mso-fareast-font-family:"Times New
Roman";mso-bidi-font-family:
"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:NL"
lang="EN-GB">For more
information about this position, please contact Dr. T. Abeel (</span><span
lang="NL"><a href="mailto:t.abeel@tudelft.nl"><span
style="font-size:
11.0pt;mso-fareast-font-family:"Times New
Roman";mso-bidi-font-family:"Times New
Roman";
mso-ansi-language:EN-GB;mso-fareast-language:NL"
lang="EN-GB">t.abeel@tudelft.nl</span></a></span><span
style="font-size:11.0pt;mso-fareast-font-family:"Times New
Roman";
mso-bidi-font-family:"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:
NL" lang="EN-GB">). To apply, please e-mail a detailed CV
(including grades and English
certification if applicable), cover letter and at least two
personal letters of
recommendation. Please submit your full application by June 1,
2016 to </span><span lang="NL"><a
href="mailto:t.abeel@tudelft.nl"><span style="font-size:
11.0pt;mso-fareast-font-family:"Times New
Roman";mso-bidi-font-family:"Times New
Roman";
mso-ansi-language:EN-GB;mso-fareast-language:NL"
lang="EN-GB"><a class="moz-txt-link-abbreviated" href="mailto:t.abeel@tudelft.nl">t.abeel@tudelft.nl</a></span></a></span><span
style="font-size:11.0pt;mso-fareast-font-family:"Times New
Roman";
mso-bidi-font-family:"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:
NL" lang="EN-GB">.<span style="mso-spacerun:yes"> </span>More
information about the
section: </span><span lang="NL"><a
href="http://bioinformatics.tudelft.nl/"><span
style="font-size:11.0pt;mso-fareast-font-family:"Times
New Roman";
mso-bidi-font-family:"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:
NL" lang="EN-GB"><a class="moz-txt-link-freetext" href="http://bioinformatics.tudelft.nl/">http://bioinformatics.tudelft.nl/</a></span></a></span><span
style="font-size:11.0pt;mso-fareast-font-family:"Times New
Roman";mso-bidi-font-family:
"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:NL"
lang="EN-GB"> and the
project leader: </span><span lang="NL"><a
href="http://www.abeel.be/"><span
style="font-size:11.0pt;mso-fareast-font-family:"Times
New Roman";
mso-bidi-font-family:"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:
NL" lang="EN-GB"><a class="moz-txt-link-freetext" href="http://www.abeel.be/">http://www.abeel.be/</a></span></a></span><span
style="font-size:
11.0pt;mso-fareast-font-family:"Times New
Roman";mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-GB;mso-fareast-language:NL" lang="EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal" style="tab-stops:center 3.15in"><span
style="font-size:5.0pt;mso-fareast-font-family:"Times New
Roman";mso-bidi-font-family:
"Times New
Roman";mso-ansi-language:EN-GB;mso-fareast-language:NL"
lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="tab-stops:center 3.15in"><b
style="mso-bidi-font-weight:
normal"><span
style="font-size:11.0pt;mso-bidi-font-family:Arial" lang="NL">Conditions
of
employment<br>
</span></b><span
style="font-size:11.0pt;mso-bidi-font-family:Arial" lang="NL">TU
Delft offers an attractive benefits package, including a
flexible work week and
the option of assembling a customised compensation and benefits
package. Salary
and benefits are in accordance with the Collective Labour
Agreement for Dutch
Universities.<br>
As a PhD candidate you will be enrolled in the TU Delft Graduate
School. TU
Delft Graduate School provides an inspiring research
environment; an excellent
team of supervisors, academic staff and a mentor; and a Doctoral
Education
Programme aimed at developing your transferable,
discipline-related and
research skills. Please visit <a class="moz-txt-link-abbreviated" href="http://www.phd.tudelft.nl">www.phd.tudelft.nl</a> for more
information.</span><span lang="NL"><o:p></o:p></span></p>
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