<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=utf-8"><meta name=Generator content="Microsoft Word 14 (filtered medium)"><!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:Wingdings;
panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:Wingdings;
panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Arial Unicode MS";
panose-1:2 11 6 4 2 2 2 2 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:"Trebuchet MS";
panose-1:2 11 6 3 2 2 2 2 2 4;}
@font-face
{font-family:"\@Arial Unicode MS";
panose-1:2 11 6 4 2 2 2 2 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p
{mso-style-priority:99;
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
span.EmailStyle18
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:#1F497D;}
span.EmailStyle19
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
/* List Definitions */
@list l0
{mso-list-id:488055324;
mso-list-template-ids:-2057826076;}
@list l0:level1
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:36.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l0:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:72.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:"Courier New";
mso-bidi-font-family:"Times New Roman";}
@list l0:level3
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:108.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level4
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:144.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level5
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:180.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level6
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:216.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level7
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:252.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level8
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:288.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level9
{mso-level-number-format:bullet;
mso-level-text:;
mso-level-tab-stop:324.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
ol
{margin-bottom:0cm;}
ul
{margin-bottom:0cm;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=NL link=blue vlink=purple><div class=WordSection1><p style='margin:0cm;margin-bottom:.0001pt'><b><span lang=EN-US style='font-size:13.5pt;font-family:"Arial","sans-serif";color:black'>BioSB Course Quantitative and Predictive Modelling</span></b><span lang=EN-US style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span lang=EN-US style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><b><span style='font-family:"Arial","sans-serif";color:black'>Date: 26-30 June, 2017</span></b><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><b><span style='font-family:"Arial","sans-serif";color:black'>Location: Wageningen</span></b><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><b><span style='font-family:"Arial","sans-serif";color:black'>Course Coordinators: Natal van Riel (TUE) & Jaap Molenaar (WUR)</span></b><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>Website: </span><span style='font-family:"Arial","sans-serif"'><a href="http://biosb.nl/education/course-portfolio-2/course-quantitative-and-predictive-modelling/">http://biosb.nl/education/course-portfolio-2/course-quantitative-and-predictive-modelling/</a><span style='color:black'> </span><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>Registration: </span><span style='font-family:"Arial","sans-serif"'><a href="http://biosb.nl/education/course-portfolio-2/course-quantitative-and-predictive-modelling/enrollment-quantitative-and-predictive-modelling-course/">http://biosb.nl/education/course-portfolio-2/course-quantitative-and-predictive-modelling/enrollment-quantitative-and-predictive-modelling-course/</a><span style='color:black'> </span><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>Please note that this course is free of charge for PhDs who are or become a</span><span style='font-family:"Arial","sans-serif"'><a href="http://biosb.nl/about/members/biosb-membership-information/"><span style='color:black'> </span>member of the BioSB research school</a><span style='color:black'>.</span><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><b><span style='font-family:"Arial","sans-serif";color:black'>Description</span></b><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>On June 26-30 2017, BioSB organises the second edition of the course Quantitative and Predictive Modelling (QPM). In this course the participants learn how to describe the dynamic behaviour of biological systems and to integrate experimental data. Concepts of modelling in terms of differential equations are introduced via a great variety of case studies taken from diverse practices. The course offers a math refresher to help those participants who are not (yet) involved in modelling on a daily basis. The emphasis is on providing an introduction into modelling approaches rather than an in-depth treatment of a few techniques and aims as such at a broad audience. The course is a mixture of theory sessions and computer practicals. During the practicals most of the time Matlab will be used. Participants not acquainted with Matlab will get an introduction. The course has to be completed with assignments in the form of practical exercises as homework afterwards.</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><b><span style='font-family:"Arial","sans-serif";color:black'>Target audience and learning objectives</span></b><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>This course is primarily targeted at academic researchers such as PhD students and Postdocs in Life Sciences, Bioinformatics, Systems Biology or Biomedical Engineering. Participants from the private sector are also welcome. Participants are expected to have some experience in modelling with differential equations. </span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:15.0pt;margin-left:0cm'><span style='font-family:"Arial","sans-serif";color:black'>The students will be provided with a theoretical basis, a variety of methods and a computational hands-on experience to handle differential equation modelling, parameter estimation and uncertainty analysis. In the course the students will learn:</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:0cm;margin-left:66.0pt;margin-bottom:.0001pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;vertical-align:baseline'><![if !supportLists]><span style='font-size:10.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-family:"Arial","sans-serif";color:black'>How to set-up a dynamic model to represent biological networks using different interaction mechanisms</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:0cm;margin-left:66.0pt;margin-bottom:.0001pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;vertical-align:baseline'><![if !supportLists]><span style='font-size:10.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-family:"Arial","sans-serif";color:black'>To implement, simulate and analyse dynamic network models in different software tools</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:0cm;margin-left:66.0pt;margin-bottom:.0001pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;vertical-align:baseline'><![if !supportLists]><span style='font-size:10.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-family:"Arial","sans-serif";color:black'>To understand the common ground and the differences for applications in metabolic, regulatory, signalling, population and multi-scale biological processes</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:15.0pt;margin-left:66.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo2;vertical-align:baseline'><![if !supportLists]><span style='font-size:10.0pt;font-family:Symbol'><span style='mso-list:Ignore'>·<span style='font:7.0pt "Times New Roman"'> </span></span></span><![endif]><span style='font-family:"Arial","sans-serif";color:black'>To integrate experimental data in modelling, estimate model parameters and assess the accuracy of parameter estimates and model predictions</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>This course is part of the</span><span style='font-family:"Arial","sans-serif"'><a href="http://biosb.nl/education/course-portfolio-2/"><span style='color:black'> </span>Education Programme of BioSB</a><span style='color:black'>, the Netherlands Bioinformatics and Systems Biology Research School, which offers training and education for in bioinformatics and systems biology.</span><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>More information about BioSB can be found at </span><span style='font-family:"Arial","sans-serif"'><a href="http://www.biosb.nl/">www.biosb.nl</a><span style='color:black'>. </span><o:p></o:p></span></p><p style='margin:0cm;margin-bottom:.0001pt'><span style='font-family:"Arial","sans-serif";color:black'>Beste regards,</span><span style='font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial","sans-serif";color:black'>Femke Francissen</span><br clear=all><o:p></o:p></p><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><p class=MsoNormal><b><span style='font-family:"Arial","sans-serif";color:black'></span></b><b><span style='font-family:"Trebuchet MS","sans-serif";color:black'><o:p></o:p></span></b></p></div><div><p class=MsoNormal><b><span style='font-family:"Arial","sans-serif";color:black'></span></b><b><span style='font-family:"Trebuchet MS","sans-serif";color:black'><o:p></o:p></span></b></p></div></div><div><div><p class=MsoNormal><b><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Femke Francissen</span></b><span style='font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Community manager BioSB</span><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>BioSB Research School</span><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div><div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Visiting address: Geert Grooteplein 28, route 260, 6525 GA Nijmegen</span><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Postal address: P.O. box 9101, route 260, 6500 HB Nijmegen</span><span style='font-size:9.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div></div><div><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p> </o:p></span></p></div></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>E-mail: </span><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";color:black'><a href="mailto:femke.francissen@biosb.nl" target="_blank"><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#1155CC'>femke.francissen@biosb.nl</span></a></span><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'> </span><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";color:black'><o:p></o:p></span></p></div><div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Mobile: +31 6 17 90 4888</span><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Skype: femke.francissen</span><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'>Website: </span><span style='font-size:9.0pt;font-family:"Arial Unicode MS","sans-serif";color:purple'><a href="http://www.biosb.nl/" target="_blank">www.biosb.nl</a></span><span style='font-size:10.5pt;font-family:"Arial Unicode MS","sans-serif";color:#484848'><o:p></o:p></span></p></div></div><div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Calibri","sans-serif";color:black'>LinkedIn <a href="http://nl.linkedin.com/in/femkefrancissen" target="_blank"><span style='color:#1155CC'>link</span></a></span><span style='font-family:"Arial","sans-serif";color:#222222'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial","sans-serif";color:#222222'><o:p> </o:p></span></p></div><div><p class=MsoNormal><img border=0 width=96 height=85 id="_x0000_i1025" src="http://www.dtls.nl/wp-content/uploads/2014/09/BioSB_logo_full_250x226.jpg"><o:p></o:p></p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></body></html>