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<div class=""><span id="docs-internal-guid-2b8b1a26-dfee-9273-9f1c-a018256c2e24" style="font-family: -webkit-standard;" class="">
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<span style="font-size: 13.999999999999998pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Post-doc in applied
mathematics: Innovative mathematical methods for the integration of proteomics and metabolomics data</span></p>
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<span style="font-size: 12pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Context</span></p>
<p dir="ltr" style="line-height: 1.3800000000000001; margin-top: 0pt; margin-bottom: 10pt; text-align: justify;" class="">
<span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Proteomics and metabolomics
</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">provide unique and complementary information
to decipher gene function and pathways, elucidate phenotypes, and robustly discover new biomarkers for disease treatments.</span></p>
<p dir="ltr" style="line-height: 1.3800000000000001; margin-top: 0pt; margin-bottom: 10pt; text-align: justify;" class="">
<span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Integration of both approaches is
a mathematical challenge</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class=""> because of the heterogeneity
and the complexity of the proteomics and metabolomics data, and the partial annotation (i.e. metabolite identification) provided by the metabolomics mass spectrometry technologies.</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">The
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">national infrastructures</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
in </span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">bioinformatics
</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">(IFB),
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">metabolomics
</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">(MetaboHUB),
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">proteomics
</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">(ProFI),
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">genomics
</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">(France Génomique), and
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">mouse phenogenomics</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
(PHENOMIN) have decided to join forces and </span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">develop
new biostatistics and bioinformatics methods and tools</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
for high-throughput and combined proteomics and metabolomics data analysis.</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Project</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">First,
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">statistical modeling</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
will be used to explore the specific and common information from each type of omics data, and to determine how their combination as molecular signatures can optimally be used to interpret and predict the phenotypes. Such approaches will include linear and
nonlinear methods for multivariate analysis.</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Second,
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">network integration</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
will be used to facilitate interpretation and annotation of the data. Proteins and metabolites will be mapped on the metabolic networks to facilitate chemical annotation and biological interpretation, and to suggest new biomarkers and metabolic functions.</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">The mathematical approaches and tools will be validated
on</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class=""> two use cases</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">:
1) the high-throughput molecular phenotyping of comprehensive collections of mouse models and 2) the discovery of new gene functions in a bacterial model of interest for environmental and biotechnological applications.</span></p>
<p dir="ltr" style="line-height: 1.3800000000000001; margin-top: 0pt; margin-bottom: 10pt; text-align: justify;" class="">
<span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Profile</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Interested applicants should have a
</span><span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">PhD in applied statistics</span><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
(data analysis, network analysis), and be motivated by multidisciplinary applications (chemistry, biology).
</span></p>
<p dir="ltr" style="line-height: 1.3800000000000001; margin-top: 0pt; margin-bottom: 10pt; text-align: justify;" class="">
<span style="font-size: 11pt; font-family: Calibri; font-weight: 700; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Contact</span></p>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Etienne Thévenot (CEA Saclay, Laboratory for Data
Analysis and Systems’ Intelligence)</span></div>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class=""><a href="mailto:etienne.thevenot@cea.fr" class="">Email:
etienne.thevenot@cea.fr</a></span></div>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Web:</span><a href="http://etiennethevenot.pagesperso-orange.fr/index.html" style="text-decoration: none;" class=""><span style="font-size: 11pt; font-family: Calibri; color: rgb(0, 0, 0); font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
</span><span style="font-size: 11pt; font-family: Calibri; color: rgb(17, 85, 204); font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; text-decoration: underline; -webkit-text-decoration-skip: none; vertical-align: baseline; white-space: pre-wrap;" class="">http://etiennethevenot.pagesperso-orange.fr/index.html</span></a></div>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">David Vallenet (CEA Evry, Laboratory of Bioinformatics
Analyses for Genomics and Metabolism)</span></div>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class=""><a href="mailto:vallenet@genoscope.cns.fr" class="">Email:
vallenet@genoscope.cns.fr</a></span></div>
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<span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">Web:
</span><a href="http://orcid.org/0000-0001-6648-0332" style="text-decoration: none;" class=""><span style="font-size: 11pt; font-family: Calibri; color: rgb(17, 85, 204); font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; text-decoration: underline; -webkit-text-decoration-skip: none; vertical-align: baseline; white-space: pre-wrap;" class="">http://orcid.org/0000-0001-6648-0332</span></a><span style="font-size: 11pt; font-family: Calibri; font-variant-ligatures: normal; font-variant-east-asian: normal; font-variant-position: normal; vertical-align: baseline; white-space: pre-wrap;" class="">
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