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<div class="">Please find hereafter a job offer for a 2 years interdisciplinary post-doc position in Marseille (France).</div>
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<p class=""><b class=""><span class="" style="font-size:11pt; font-family:LiberationSerif,serif">Project</span></b><span class="" style="font-size:11pt"></span></p>
<p class="x_x_MsoNormal" style="margin-bottom:12pt"><font face="Times New Roman" class="" style="font-size:15px"><span lang="EN-GB" class="">The aim of the project</span><span lang="EN-GB" class=""> </span>is to characterize molecular pathways deregulated in
myelofibrosis development and define predictive factors of disease evolution. <span lang="EN-GB" class="">Hematopoietic tissue is sensitive to aging, which results in senescence and haematological age-related diseases like </span><i class="">myelofibrosis.</i> We
propose an interdisciplinary approach focused on the understanding of the hematopoietic stem cell (HSC)/stromal cell cross-talk that evolves during aging and favors myelofibrosis.<span lang="EN-GB" class=""></span></font></p>
<p class="x_x_MsoNormal" style="margin-bottom:12pt"><font face="Times New Roman" class="" style="font-size:15px"><b class=""> </b><span lang="EN-GB" class="">The applicant will be in charge of the establishment and analysis of mathematical models
centered on bone marrow and HSC aging in order to better understand haematological age-related disease onset. We have developed a unique mouse model, which recapitulates physiological and pathological aging that will be used to </span></font><span lang="EN-GB" class=""><font face="Times New Roman" class=""><span class="" style="font-size:15px">generate
single cell transcriptomic data. The generated data, together with an extensive literature study, will be the base to address the complexity of the network deregulated upon HSC/stromal cell aging by mathematical modeling approaches.</span><span class="" style="font-size:11pt"></span></font></span></p>
<p class=""><font face="Times" class="" style="font-size:15px"><b class="">Environment</b><b class=""></b></font></p>
<p class=""><span class="" style="font-size:15px"><font face="Times New Roman" class="">The successful applicant will work in the <i class="">Mathematics and Algorithms for Systems Biology </i>(Mabios, <span class="" style="color:rgb(15,84,204)"><a href="http://mabios.math.cnrs.fr/index.html" class="">http://mabios.math.cnrs.fr/index.html</a></span>)
group in the Marseille Institute of Mathematics (I2M, Aix-Marseille University) an interdisciplinary team of mathematicians and computational biologists, in close collaboration with the <i class="">E. Duprez </i>team (<span class="" style="color:rgb(15,84,204)"><a href="http://crcm.marseille.inserm.fr/en/researchteams/estelle-duprez" class="">http://crcm.marseille.inserm.fr/en/researchteams/estelle-duprez</a>)</span>,
specialised in Epigenetic Factors in Normal and Malignant Hematopoiesis</font><font face="Times New Roman" class=""> in the Centre de Recherche en Cancérologie de Marseille (CRCM).</font></span><span class="" style="font-size:11pt; color:rgb(15,84,204)"></span></p>
<p class=""><b class=""><span lang="EN-GB" class="" style="font-size:15px"><font face="Times" class="">Expected profile</font></span></b></p>
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<p class=""><font face="Times New Roman" class="" style="font-size:15px"><span lang="EN-GB" class="">Th</span>e applicant should have a formation (PhD) in Computer Science, Applied Mathematics, Computational Biology (or related fields). He/she should have a
strong interest in biology and interdisciplinary approaches to decipher biological processes. Skills in programming/scripting and/or bioinformatics (for *-seq data processing) would be an advantage.</font></p>
<p class=""><b class=""><span class="" style="font-size:11pt; font-family:LiberationSerif,serif">Offer</span></b><span class="" style="font-size:11pt"></span></p>
<p class=""><font face="Times New Roman" class="" style="font-size:15px">Fully-funded position for 2 years in Marseille. The starting date is expected in January 2019. Application can be sent directly to “<span class="" style="color:rgb(15,84,204)"><a href="mailto:elisabeth.remy@univ-amu.fr" class="">elisabeth.remy@univ-amu.fr</a></span>”
and “<span class="" style="color:rgb(15,84,204)"><a href="mailto:estelle.duprez@inserm.fr" class="">estelle.duprez@inserm.fr</a></span>”. Please make sure your application includes a letter of motivation, a list of publications, a detailed CV and the contact
information of 2 references (including email addresses and phone numbers). </font></p>
<p class=""><b class=""><span class="" style="font-size:11pt"><font face="Times" class="">Keywords</font>:<font face="Times New Roman" class=""> </font></span></b><font face="Times New Roman" class=""><span class="" style="font-size:11pt">Mathematical modeling,<b class=""> </b></span><span class="" style="font-size:11pt">Single
cell, Data Analysis, Systems Biology</span></font><span class="" style="font-size:12pt; font-family:LiberationSerif,serif"></span></p>
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<div class="" style="word-wrap:break-word">Élisabeth REMY<br class="">
Institut de Mathématiques de Marseille (I2M)</div>
<div class="" style="word-wrap:break-word">Campus de Luminy- Case 907<br class="">
13288 Marseille cedex 09<br class="">
+33 (0)4 91 26 95 65<br class="">
<a href="http://mabios.math.cnrs.fr/index.html" class="">http://mabios.math.cnrs.fr/index.html</a><br class="">
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