<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class="">PhD/POSTDOC POSITION: </div><div class="">‘CellCircuits: Mining a genomics compendium to identify therapeutic targets’ </div><div class=""> </div><div class="">CONSORTIUM PARTNERS:</div><div class="">Wessels Laboratory, The Netherlands Cancer Institute (NKI), Amsterdam.</div><div class="">Brummelkamp Laboratory, The Netherlands Cancer Institute (NKI), Amsterdam.</div><div class="">Scenic Biotech BV, Amsterdam, The Netherlands</div><div class=""><br class=""></div><div class="">PROJECT DESCRIPTION: </div><div class="">Human cells perform highly complex tasks and are equipped with the required machinery and decision-making processes that largely remain poorly understood. Although human genes play a central role, no wiring diagram exists depicting their function. This project will link the function of all human genes to a compendium of cellular processes. This will suggest new entry points to manipulate cellular processes and therapeutic strategies to rebalance disease. </div><div class=""><br class=""></div>
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<!--StartFragment--><!--EndFragment--><div class=""><span style="font-size: 10.5pt;" class="">PUBLIC-PRIVATE, MULTI-DISCIPLINARY COLLABORATION:</span></div><div class="">This consortium will draw upon 1) Phenosaurus, a large collection (~130) of haploid screens generated in collaboration with Scenic Biotech BV employing the Cell-seq technology developed by the Brummelkamp laboratory; 2) the screening, cell and molecular biology expertise of the Brummelkamp laboratory and the computational know-how of the Wessels laboratory. With the Cell-seq technology proven to be highly effective, the opportunity exists now to cover diverse cellular functions and to use advanced computational network inference approaches to deduce the underlying genetic control mechanisms. </div><div class=""><br class=""></div><div class="">EMBEDDING:</div><div class="">The successful candidate will be employed in the Wessels and Brummelkamp groups at the Netherlands Cancer Institute, and will regularly liaise with Scenic Biotech to generate sufficient cohesion and momentum.</div><div class=""><br class=""></div><div class="">CANDIDATE PROFILE: </div><div class="">We are seeking a highly motivated PhD candidate with:</div><div class="">•<span class="Apple-tab-span" style="white-space:pre"> </span>A degree in bioinformatics, computer science or a related discipline</div><div class="">•<span class="Apple-tab-span" style="white-space:pre"> </span>Experience in statistics, machine learning and/or pattern recognition </div><div class="">•<span class="Apple-tab-span" style="white-space:pre"> </span>Proficiency in bioinformatics programming languages (e.g. R, Python)</div><div class="">•<span class="Apple-tab-span" style="white-space:pre"> </span>Good cross-disciplinary collaborative and communication skills </div><div class="">•<span class="Apple-tab-span" style="white-space:pre"> </span>Experience in analysing high-throughput molecular data is a plus</div><div class="">•<span class="Apple-tab-span" style="white-space:pre"> </span>Experience in cancer biology and clinical applications is a plus</div><div class=""><br class=""></div><div class="">INTERESTED? Please send a CV and motivation letter to Lodewyk Wessels (<a href="mailto:l.wessels@nki.nl" class="">l.wessels@nki.nl</a>).</div><div class="">Please include the names and contact information of at least two references.</div><div class=""><br class=""></div><div class="">WANT MORE INFORMATION?<br class="">Visit our websites:</div><div class=""><span class="" style="float: none; display: inline !important;">Wessels lab: Computational Cancer Biology: </span><a href="http://ccb.nki.nl" class="">ccb.nki.nl</a><br class="">Brummelkamp lab: <a href="https://www.nki.nl/divisions/biochemistry/brummelkamp-t-group/" class="">https://www.nki.nl/divisions/biochemistry/brummelkamp-t-group/</a></div><div class="">or contact <span class="" style="float: none; display: inline !important;">Lodewyk Wessels, </span><a href="mailto:l.wessels@nki.nl" class="">l.wessels@nki.nl</a></div><div class=""><br class=""></div><div class="">DEADLINE: 1 October 2019</div><div class=""><br class=""></div><div class="">RELEVANT LITERATURE:</div><div class="">van de Haar J, Canisius S, Yu MK, Voest EE, Wessels LFA, Ideker T. Identifying Epistasis in Cancer Genomes: A Delicate Affair. Cell. 2019 May 30;177(6):1375-1383.</div><div class="">Aben N, Westerhuis JA, Song Y, Kiers HAL, Michaut M, Smilde AK, Wessels LFA. iTOP: inferring the topology of omics data. Bioinformatics. 2018 Sep 1;34(17):i988-i996. </div><div class="">Brockmann, M., Blomen, V.A., Nieuwenhuis, J., Stickel, E., Raaben, M., Bleijerveld, O.B., Altelaar, A.F.M., Jae, L.T. 1 and Brummelkamp, T.R1. (2017) Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature 546, 307-311.</div><div class="">Nieuwenhuis, J., Adamopoulos, A., Bleijerveld, O.B., Mazouzi, A., Stickel, E., Celie, P., Altelaar, M., Knipscheer, P., Perrakis, A., Blomen, V.A., and Brummelkamp, T.R. (2017) Vasohibins encode tubulin detyrosinating activity. Science 6369, 1453-1456.</div><div class="">Mezzadra, R. 1, Sun, C. 1, Jae, L.T. 1, Gomez-Eerland, R., de Vries, E., Wu, W., Logtenberg, M.E.W., Slagter, M., Rozeman, E.A., Hofland, I., Broek,s A., Horlings, H.M., Wessels, L.F.A., Blank, C.U., Xiao, </div><div class=""><br class=""></div></body></html>