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<div class="WordSection1">
<p style="line-height:16.5pt;background:white"><span style="font-size:12.0pt;color:black">I</span><span style="font-size:12.0pt;color:#232642"> am seeking a highly motivated computational
<b><u>postdoc</u></b> and <b><u>staff scientist</u></b> to join <a href="https://www.sanger.ac.uk/group/martin-group/">
my group </a>at the Wellcome Sanger Institute. The group investigates the genetic basis of rare and common diseases and complex traits, primarily in populations with European and South Asian ancestry. We currently have projects in the following areas:<o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:#232642;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3;background:white;box-sizing: inherit;font-size:1rem;padding-left:0.35rem">
<span style="font-size:12.0pt">The role of both rare and common variants in rare developmental disorders, using data from the <a href="https://www.sanger.ac.uk/collaboration/deciphering-developmental-disorders-ddd/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Deciphering
Developmental Disorders</span></a> study (N=13,000 exome-sequenced patients) and the Genomics England <a href="https://www.genomicsengland.co.uk/about-genomics-england/the-100000-genomes-project/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">100,000
Genomes project</span></a> (N~33,000 whole-genome sequenced rare disease patients), in collaboration with GeneDx (>60,000 exome sequenced patients) and with <a href="https://www.sanger.ac.uk/group/hurles-group/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Matt
Hurles’ group</span></a>. We have a particular focus on the contribution of recessive variants across diverse populations (building on <a href="https://www.science.org/doi/10.1126/science.aar6731" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">previous
work</span></a>), and on the interplay of rare and common variants. We are also beginning new projects investigating the genetic contribution to sex differences in autism and autistic traits, and on the impact of endogamy versus consanguinity on rare disease
risk.<o:p></o:p></span></li><li class="MsoNormal" style="color:#232642;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3;background:white;box-sizing: inherit;font-size:1rem;padding-left:0.35rem">
<span style="font-size:12.0pt">The genetics of cognitive and behavioral traits, using sequence and genotype data from UK Biobank and from two large UK birth cohorts, the <a href="http://www.bristol.ac.uk/alspac/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Avon
Longitudinal Study of Parents and Children</span></a> and the <a href="https://cls.ucl.ac.uk/cls-studies/millennium-cohort-study/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Millenium Cohort Study</span></a> (N~20,000),
in collaboration with with <a href="https://www.sanger.ac.uk/group/hurles-group/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Matt Hurles’ group</span></a>. This work is building on recent findings about the genetic
overlap between rare neurodevelopmental disorders and cognitive/mental health traits in the general population (e.g. <a href="https://www.nature.com/articles/s41586-018-0566-4" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Niemi
et al., Nature, 2018</span></a>; <a href="https://www.nature.com/articles/s41586-022-04549-9" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Gardner et al., Nature, 2022</span></a>).<o:p></o:p></span></li><li class="MsoNormal" style="color:#232642;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3;background:white;box-sizing: inherit;font-size:1rem;padding-left:0.35rem">
<span style="font-size:12.0pt">The genetic basis of complex diseases and traits in British South Asian populations, using data from the <a href="https://www.genesandhealth.org/" target="_blank" title="* this link opens in a new window/tab"><span style="color:#597FBA">Genes
& Health project</span></a> (N~50,000 British Pakistani and Bangladeshi individuals with linked electronic health records). An industry consortium has recently funded exome-sequencing of the cohort to complement the existing genotype chip data. We are investigating
the contribution of rare and common variants to complex disease risk, as well as the role of autozygosity.<o:p></o:p></span></li></ul>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:16.5pt;background:white">
<b><span style="font-size:12.0pt;color:black">Both are three-year posts</span></b><span style="font-size:12.0pt;color:black">. Please get in touch if either sounds of interest.</span><i><span style="font-size:12.0pt;color:#232642;mso-fareast-language:EN-GB">
</span></i><span style="font-size:12.0pt;color:#232642;mso-fareast-language:EN-GB">Applications will be considered on an ongoing basis and the role will close when a successful appointment has been made.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><a href="https://jobs.sanger.ac.uk/vacancy/computational-postdoctoral-fellow-in-medical-genomics-486451.html">https://jobs.sanger.ac.uk/vacancy/computational-postdoctoral-fellow-in-medical-genomics-486451.html</a>
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><a href="https://jobs.sanger.ac.uk/vacancy/computational-senior-staff-scientist-medical-genetics-486465.html">https://jobs.sanger.ac.uk/vacancy/computational-senior-staff-scientist-medical-genetics-486465.html</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt">Best wishes,<br>
Hilary Martin<o:p></o:p></span></p>
</div>
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