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<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">Dear colleagues,</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span style="color:#201f1e"><u></u> <u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">Also in this academic year the BioSB research school, Wageningen University & Reserach </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">and Eindhoven University of Technology will organize the course:</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span style="color:#201f1e"><u></u> <u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">*Integrated Modeling and Optimization*</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">12-16 December 2022, Wageningen University</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> 
Website: <a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-2022/">https://www.dtls.nl/courses/integrated-modeling-and-optimization-2022/</a></span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">Computational modelling is an absolute requisite to gain understanding of</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">the biological mechanisms underlying patterns observed in experimental</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">data. However, one could say that modelling is a craftsmanship, that can</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">only be learned via intense exercising and ‘learning by doing’. In this</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">course we offer the participants the possibility to learn and exercise the</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">modeling process and the optimization techniques needed to fit models to</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">data.</span> </pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span> </pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">In the course the students will learn:</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - to understand the common ground and the differences for applications</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   of dynamic modeling in metabolic, regulatory, signaling, and multi-scale</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   biological processes</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - how to set-up a dynamic model to represent biological networks using</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   different interaction mechanisms</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - to implement, simulate and analyze dynamic network models</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - to understand the wide variety of problems in modelling that can be</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   solved with optimization ·</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - to apply different types of numerical optimization methods: global and</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   local search methods: steepest descent, Levenberg-Marquardt, genetic</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   algorithms, linear programming.</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - the combination of dynamic modeling and optimization to integrate</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   experimental data in modelling, estimate model parameters and design</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   experiments.</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   - to understand how numerical optimization (linear programming) works in</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">   flux balance analysis to simulate metabolic network models.</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">Lecturers:</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="margin-left:36.0pt;background:white"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959">·        Prof. Natal van Riel, Eindhoven University of Technology (course coordinator)</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="margin-left:36.0pt;background:white"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959">·        Dr. Aalt-Jan van Dijk, Wageningen University & Research</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="margin-left:36.0pt;background:white"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959">·        Prof. Jaap Molenaar, Wageningen University & Research</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="margin-left:36.0pt;background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959">·        Dr. Hans Stigter, Wageningen University & Research</span><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="margin-left:36.0pt;background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959">·        Dr. Robert Smith, Wageningen University & Research</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="margin-left:36.0pt;background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959">·        Dr. Dragan Bosnacki, Eindhoven University of Technology</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">Target audience:</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e">The course is aimed at PhD students with a background in bioinformatics, systems biology, computer science or a related field</span><span style="font-size:12.0pt;color:#201f1e">,</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959;background:white">and life sciences. Participants from the private sector are also welcome. A working knowledge of mathematics,</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959;background:white">especially differential equations, is recommendable, but we will distribute preparation material to be studied by students</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959;background:white">missing the required background. Furthermore, at the start we offer a math refresher to help those participants who </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#595959;background:white">are not (yet) involved in modelling on a daily basis.</span><span style="color:#201f1e"><u></u><u></u></span></pre>
<pre style="background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"> </span><span style="color:#201f1e"><u></u><u></u></span></pre>
<div><div style="margin-top:12.0pt;margin-bottom:12.0pt;min-width:424px"><pre style="text-align:center;background:white"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:#201f1e"></span><span style="color:#201f1e"><u></u><u></u></span></pre>
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</div></div><br clear="all"><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><p class="MsoNormal" style="margin-bottom:12pt;line-height:normal;background-image:initial;background-position:initial;background-repeat:initial"><a name="SignatureSanitizer__MailAutoSig"><span lang="EN-US" style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black">Dr. Celia W.G. van Gelder<br>
</span></a><span style="font-family:Arial,sans-serif"><font color="#000000"><span style="font-size:10.5pt">Training Programme Manager DTL/ELIXIR-NL/Health-RI</span></font><br><span style="font-size:16px">Network Manager TDCC-LSH</span></span></p><p class="MsoNormal" style="margin-bottom:12pt">

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