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<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
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<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">The BioSB research
school is happy to invite you to</span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
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the <font size="2"><b><br>
</b></font></span></font></p>
<p class="MsoNormal" style="margin-bottom:0cm;line-height:normal;background:#F8F8F8">
<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB"><font size="2"><b>HotTopic
Symposium:</b></font></span></font></p>
<font size="1"></font>
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normal;background:#F8F8F8">
<font size="1"><b><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"><a href="https://www.dtls.nl/events/biosb-hottopics-symposium-computational-methods-for-spatial-data-analysis/" target="_blank">Computational
Methods for (single cell) Spatial Data Analysis</a></span></b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000">
<span lang="EN-GB">– LUMC Leiden, 17 November 2023 (Free entrance after registration)</span></span></font></p>
<font size="1"><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
BioSB and ‘single cell network Netherlands’ (scNL) are co-organising </span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB">this</span><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
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mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000">
symposium</span><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB">.
</span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">The goal of this informal meeting
is to bring together people who are interested in this topic in order to learn about the latest development, and to build a community.<br>
</span></font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB">For
more information <a href="https://www.dtls.nl/events/biosb-hottopics-symposium-computational-methods-for-spatial-data-analysis/">
click here.<b><span style="mso-ansi-language:#2000" lang="en-NL"> </span></b></a></span><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">
</span></b></font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font><br>
<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"><br>
BioSB also announces that registration is open for <br>
<br>
<font size="2"><b>BioSB course</b>:</font></span></font><font size="1"><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></b></font>
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margin-left:36.0pt;line-height:normal;background:#F8F8F8">
<font size="1"><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">
</span></b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"></span></font></p>
<font size="1"><b><u><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"><a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" target="_blank" moz-do-not-send="true">Integrated
Modeling and Optimization</a></span></u></b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">
- Wageningen, 11 - 15 December 2023 (early bird fee till October 16)</span><br style="mso-special-character:line-break">
<span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font>
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margin-left:36.0pt;line-height:normal;background:#F8F8F8">
<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:black;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
</span></font></p>
<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:black;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000">In validating
models one always meet with the need to fit models to data. So, the parameters that are present in any realistic model have to be chosen based on comparison of model predictions with data. In this matching process <b>optimization techniques</b> are indispensable.
That’s why a considerable part of this course is spent on getting you acquainted with the optimization techniques that are nowadays available and widely used. Numerical optimization also is the basis for so-called flux balance analysis (FBA), commonly used
to study large metabolic networks. This type of models and their analysis and simulation is also introduced in the course.</span></font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB"><br>
<br>
For more information <a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" moz-do-not-send="true">
click here</a>.</span><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"> </span></b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:black;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"></span></font><font size="1"><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">
</span></b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font><font size="1"></font><br>
<font size="1"><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB"><br>
Last but not least: please mark your calendars and <font color="#ff0000"><b>SAFE THE DATE</b></font><font size="2"><b>
</b>for</font></span></font><font size="1"><font size="2"><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"></span><b><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
<br>
The BioSB 2024 </span></b></font><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"><font size="2"><b>conference:</b></font></span></font><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"><b>
</b><font size="2"><b>18 - 19 June 2024</b><b>, Egmond aan Zee, NL.</b></font></span><font size="1"><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
More information will follow soon!</span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB"></span></font><br>
<font size="1"></font>
<p class="MsoNormal" style="margin-bottom:0cm;line-height:normal;background:#F8F8F8">
<font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">We hope to see many
of you </span><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB">at</span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">
one of the BioSB events </span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB">and</span><span style="font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;
mso-ligatures:none;mso-ansi-language:#2000;mso-fareast-language:#2000">
courses</span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB">. Be
welcome!</span></font></p>
<font size="1"></font><font size="1"><br>
<span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB">Best regards,</span><br>
<span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB">Petra Aarnoutse</span><br>
</font><font size="2"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:EN-GB;
mso-fareast-language:#2000" lang="EN-GB"><font size="1">BioSB
community manager<br>
<br>
</font><img src="cid:part1.pLKCtXnZ.4aYrC2St@health-RI.nl" alt="" class=""><br>
</span></font></div>
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