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<b><font size="2">Dear Colleagues,</font></b><br>
<div class="moz-forward-container"><font size="2">Please note, there are</font> <font size="4" color="#ff0000">
<b>still four days to register at an early-bird reduced rate</b></font><font color="#ff0000">
<font size="2" color="#000000">for the BioSB course:</font></font><br>
<div class="moz-forward-container"><font color="#ff0000">
</font><br>
<blockquote>
<p><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"><font size="2"> </font></span></font><font size="1"><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
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</span></b><font size="4"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"></span></font></font><font size="4"><b><u><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"><a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" originalsrc="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" shash="EC/va83OR+z0T4NfQU8/r3wFxLA2RWAQ9GMNvQrRs+uPbeeyCitdZYLVipDbW3XrUOEk8VPKfM094tmXR/1oayWVN1X8KFHwNbdroyvh/UK5z3hMOjbUjdx0ZYb/e8asM2RMZ4f3Sgb8ATprqcp0M5FKI3M4XtIwP1lZktD8Iro=" target="_blank" moz-do-not-send="true">Integrated
Modeling and Optimization</a></span></u></b></font></p>
<font size="4"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">
<b>W</b></span><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">a</span></b><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">geningen,
11 - 15 December 2023 (early bird fee until October 16)</span></b></font><font size="4" color="#ff0000"><b>
</b></font><font color="#ff0000"><br>
</font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font><br>
</blockquote>
<font size="2"><b>What it's about?</b><b><br>
<br style="mso-special-character:line-break">
</b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span><span style="background:
white none repeat scroll 0% 0%;">In
validating models one always meet with the need to fit models to data. So, the parameters that are present in any realistic model have to be chosen based on comparison of model predictions with data. In this matching process <b>optimization techniques</b> are
indispensable. That’s why a considerable part of this course is spent on getting you acquainted with the optimization techniques that are nowadays available and widely used. Numerical optimization also is the basis for so-called flux balance analysis (FBA),
commonly used to study large metabolic networks. This type of models and their analysis and simulation is also introduced in the course.</span><span style="background: white none repeat scroll 0% 0%;" lang="EN-GB"><br>
</span><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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color:#1D1C1D;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB"><br>
</span><span style="background: white none repeat scroll 0%
0%;" lang="EN-GB"><b>More information and registration: </b>
<a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" originalsrc="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" shash="EC/va83OR+z0T4NfQU8/r3wFxLA2RWAQ9GMNvQrRs+uPbeeyCitdZYLVipDbW3XrUOEk8VPKfM094tmXR/1oayWVN1X8KFHwNbdroyvh/UK5z3hMOjbUjdx0ZYb/e8asM2RMZ4f3Sgb8ATprqcp0M5FKI3M4XtIwP1lZktD8Iro=" moz-do-not-send="true">
click here</a>.</span><b> <br>
<br>
</b>We look forward to welcoming you.<b><br>
</b><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
</span></b>Kind regards,<br>
Petra Aarnoutse<br>
Community manager BioSB<b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
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"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
</span></b></font><font size="1" color="#999999"><img src="cid:part1.c5aevw0a.AiUrJ7j9@health-RI.nl" alt="" class=""></font><font size="1"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
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