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<font size="1"><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></b><font size="4"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"></span></font></font><font size="2">Dear
colleagues,<br>
<br>
</font><font size="2">Grab your chance to join the upcoming BioSB course, there are still some spots available!</font>
<p><font size="4"><b><u><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"><a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/" target="_blank">Integrated
Modeling and Optimization</a></span></u></b></font></p>
<font size="4"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span></font><font size="2"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"><b>W</b></span><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">a</span></b><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">geningen,
11 - 15 December 2023 </span></b></font><font color="#ff0000"><br>
</font><font size="2"><b><br style="mso-special-character:line-break">
</b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000"></span><span style="background:
white none repeat scroll 0% 0%;">In
validating models one always meet with the need to fit models to data. So, the parameters that are present in any realistic model have to be chosen based on comparison of model predictions with data. In this matching process <b>optimization techniques</b> are
indispensable. That’s why a considerable part of this course is spent on getting you acquainted with the optimization techniques that are nowadays available and widely used. Numerical optimization also is the basis for so-called flux balance analysis (FBA),
commonly used to study large metabolic networks. This type of models and their analysis and simulation is also introduced in the course.<br>
<br>
</span></font>
<p style="box-sizing: border-box; margin: 0px 0px 10px; color: rgb(89, 89, 89); font-family: "Open Sans", sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">
<font size="2" color="#000000"><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;mso-ansi-language:#2000;
mso-fareast-language:#2000">Target
audience</span></b></font></p>
<font size="2">The course is aimed at PhD students with a background in bioinformatics, systems biology, computer science or a related field, and life sciences. Participants from the private sector are also welcome. A working knowledge of mathematics, especially
differential equations, is recommendable, but we will distribute preparation material to be studied by students missing the required background. Furthermore, at the start we offer a math refresher to help those participants who are not (yet) involved in modelling
on a daily basis.<br>
</font><br>
<font size="2"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB"></span></font><font size="2"><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:"Times
New Roman";
color:#1D1C1D;background:white;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:EN-GB;mso-fareast-language:#2000" lang="EN-GB"></span></font><span style="background: white none repeat scroll 0%
0%;" lang="EN-GB"><b>More
information: </b></span><font size="2"><span style="background: white none repeat scroll 0%
0%;" lang="EN-GB"><a href="https://www.dtls.nl/courses/integrated-modeling-and-optimization-fundamental/">click here</a>.</span><b>
<br>
<br>
</b></font><b><a href="https://www.aanmelder.nl/integrated_modeling/subscribe"><font color="#ff0000">Registration
</font></a></b><font size="2"><b><br>
<br>
</b>We look forward to welcoming you.<b><br>
</b><b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
</span></b>Kind regards,<br>
Petra Aarnoutse<br>
Community manager BioSB<b><span style="font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
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"Times New
Roman";color:#1D1C1D;mso-font-kerning:0pt;mso-ligatures:none;
mso-ansi-language:#2000;mso-fareast-language:#2000"><br>
</span></b></font><font size="1" color="#999999"><img src="cid:part1.gtMf3b8Y.pGBav90s@health-RI.nl" alt="" class=""></font>
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