[Seminars] PSB event reminder
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Thu Dec 2 09:10:01 CET 2010
Calendar Name: seminars
Scheduled for: Thursday, December 2 2010, 11:00 - 12:30
Event text: Pascal Genschik
Institut de Biologie Moléculaire des Plantes du CNRS
IBMP-CNRS - UPR2357
Strasbourg
FRANCE
Details: "CUL4-DDB1 is required to maintain epigenetic gene
repression via its interaction with the Arabidopsis PRC2
complex"
ABSTRACT
Protein ubiquitylation regulates a broad variety of
biological processes in all eukaryotes. Recent work
identified a novel class of cullin-RING ligase (CRL)
composed of CUL4, DDB1, and one substrate receptor also
called DCAF (DDB1 and CUL4-associated factors). DCAFs
are WD40 proteins containing WDxR motifs that are
required for efficient binding to DDB1. In both human
and Arabidopsis, about 90 different DCAFs have been
predicted, but for most of them their function or
substrates remain still unknown.
Among putative Arabidopsis DCAFs we identified MSI1,
which belongs to an evolutionary conserved protein
family. MSI1-like proteins contribute to different
protein complexes, including the epigenetic regulatory
Polycomb Repressive Complex2 (PRC2). Here we will
present evidence that Arabidopsis MSI1 physically
interacts with DDB1 and is part of a multimeric
CRL4-type E3 complex. Interestingly the CUL4-DDB1MSI1
complex is required to maintain parental imprinting of
MEA, a target gene of the Arabidopsis PRC2 complex.
Moreover, we extended these studies to another MSI1-like
protein, called MSI4/FVE, which is involved in the
regulation of flowering time. Overall, we will discuss
the mechanism by which CRL4s are required to maintain
Polycomb-mediated gene repression.
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