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Calendar Name: seminars
Scheduled for: Friday, October 12 2012, 14:00 - 15:30
Event text:    Dr Arp Schnittger
	       
	       Department of Molecular Mechanisms of Phenotypic
	       Plasticity 
	       Institut de Biologie Moléculaire des Plantes du CNRS
	       Université de Strasbourg
	       
	       Strasbourg
	       FRANCE
Details:       “How to make stable decisions in cell proliferation and
	       differentiation”
	       
	       ABSTRACT
	       The decision to replicate its DNA is of crucial
	       importance for every cell and in many organisms decisive
	       to progress through the entire cell cycle. Using pollen
	       as a model system, we have identified a general
	       regulatory cascade controlling entry into S phase in
	       many if not all Arabidopsis cells. This cascade
	       comprises the Arabidopsis homologs of the animal
	       transcription factor E2F, the plant homolog of the
	       animal transcriptional repressor Retinoblastoma
	       (Rb)-related 1 (RBR1), the plant-specific F-box protein,
	       F-BOX-LIKE 17, the plant specific cyclin-dependent
	       kinase (CDK) inhibitors KRPs, as well as CDKA;1, the
	       plant homolog of the yeast and animal Cdc2+/Cdk1
	       kinases. Biomathematical simulations and subsequent
	       experimental confirmation of computational predictions
	       revealed that this regulatory circuit can give rise to
	       hysteresis highlighting the identified dosage
	       sensitivity of CDK inhibitors in this network.
	       Remarkably, many components of this cell cycle control
	       module appear to function in the control of asymmetric
	       division and cell fate specification as well. I will
	       present data from our team showing that RBR1 not only
	       controls cell proliferation but also cell
	       differentiation genes during root meristem and stomata
	       development. This leads to a CDKA;1-dose dependent model
	       of formative divisions in which low and medium levels of
	       CDKA;1 are sufficient for symmetric divisions but high
	       kinase levels being required for asymmetric divisions.
	       An important aspect of this wiring is again the
	       hysteretic behavior of the system revealing an intimate
	       connection between cell cycle progression and cell fate
	       acquisition.

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