[Seminars] PSB event reminder

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Calendar Name: seminars
Scheduled for: Thursday, September 6 2012, 14:00 - 15:30
Event text:    Prof Alexander Vainstein
	       
	       Institute of Plant Sciences and Genetics in Agriculture
	       The Robert H. Smith Faculty of Agriculture, Food and
	       Environment
	       The Hebrew University of Jerusalem
	       
	       Rehovot	
	       Israel
Details:       POSTDOC INNOVATION SEMINAR
	       
	       “Permanent genome modifications in plant cells by
	       transient viral vectors”
	       
	       ABSTRACT
	       The ability to modify genome sequences in plant cells is
	       fundamental to modern agriculture. Naturally occurring
	       and artificial rare-cutting endonucleases (i.e. zinc
	       finger nuclease, homing endonuclease or TAL effector
	       nuclease) have been used for targeted mutagenesis in
	       model and crop species. However, stable transformation
	       is the preferred method for gene expression in plant
	       species, and nuclease-expressing transgenic plants have
	       been used for recovery of mutants that are likely to be
	       classified as transgenic due to the use of direct
	       gene-transfer methods into the target cells. We
	       developed an alternative, non-transgenic approach for
	       nuclease delivery and production of mutant plants using
	       a novel Tobacco rattle virus (TRV)-based expression
	       system for indirect transient delivery of nucleases into
	       a variety of tissues and cells of intact plants. Since
	       viral vectors can spread into the growing and developing
	       tissues of infected plants, the novel approach of
	       genome-editing provides a unique opportunity to bypass
	       the regeneration step that is often required in direct
	       gene-transfer methods.

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