[Seminars] You are invited to attend “ATP production in mitochondria through respiration and its use for protein homeostasis in plants” ON October 30, 2023 in ROOM L5 at CMB

[Delphine Verspeel]

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'' ATP production in mitochondria through respiration and its use for protein homeostasis in plants '' 



Prof Harvey Millar 




ARC Centre of Excellence in Plant Energy Biology 
The University of Western Australia 
Perth 
AUSTRALIA 








Monday, October 30, 2023 
15:00 

















Cellular respiration is a foundational biochemical process linking the oxidative decarboxylation of organic acids to the generation of ATP for use in biosynthesis and cellular maintenance. I will outline recent work we have been conducting to understand the rate of this process. This includes determining the transport routes for primary organic acid substrates that plant mitochondria use to generate ATP and also new insights into the efficiency of ATP generation inside plant mitochondria through the electron transport chain. I will then outline a systematic means using proteomics technology to measure the investment of this ATP through protein synthesis to build the steady-state (but constantly turning over) metabolic machinery of the plant cell. Using progressive labelling approaches with stable isotope we have studied changes in energy use patterns during high light and during periods of darkness in Arabidopsis through varying rates of protein synthesis and protein degradation of specific enzymes and biochemical pathways. I will outline how we are using these insights in research focused on crop plants in the field, the emerging requirements for vertical farming and plant-based protein production, right through to new opportunities for plants as critical systems in provisioning future space exploration. Collectively these approaches aim to return us from the current re-occupation in molecular plant science with amounts of components to consider more fully the rates of processes that drive growth and plant productivity. 




Le XH, Lee CP, Millar AH (2021) The mitochondrial pyruvate carrier (MPC) complex is one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism. Plant Cell 33:2776-2793. 

Le XH, Lee CP, Monachello D, Millar AH (2022) Metabolic evidence for distinct pyruvate pools inside plant mitochondria. Nature Plants 8:694-705 

Duncan O, Millar AH. (2022) Day and night isotope labelling reveal metabolic pathway specific regulation of protein synthesis rates in Arabidopsis. Plant J. 109:745-763. 

Li L, Duncan O, Ganguly DR, Lee CP, Crisp PA, Wijerathna-Yapa A, Salih K, Trösch J, Pogson BJ, Millar AH. (2022) Enzymes degraded under high light maintain proteostasis by transcriptional regulation in Arabidopsis. Proc Natl Acad Sci U S A. 119(20):e2121362119. 








Room L5 
Center for Medical Biotechnology 
Technologiepark 75 







Invited by Prof Dirk Inzé, Prof Frank Van Breusegem, Prof Ive De Smet, Prof Geert De Jaeger and Prof Inge De Clercq 

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Genome editing, cutting-edge technology for a sustainable agriculture 

VIB-UGent Center for Plant Systems Biology Ghent University 
Technologiepark-Zwijnaarde 71 
9052 Ghent-Belgium 
Phone: +32(0)9 331 38 00 
[ http://www.psb.vib-ugent.be/ | https://www.psb.ugent.be/ ] 











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