The Comparative Genomics group of Martijn Huynen (CMBI, Radboud University Medical Centre, Nijmegen) has a position for a talented and motivated scientist to do bioinformatics research into unraveling the patterns behind intellectual disability. We have compiled a catalogue of more than 600 genes, mutations in which give rise to intellectual disability. Several of these genes have already been demonstrated to act together in molecular pathways. However, a global overview of the biological coherence underlying intellectual disability genes is missing and the link between molecular pathways and the various intellectual disability phenotypes has not been established. The challenge is to address this, e.g. via analyzing protein-protein interactions, tissues specific gene expression, shared phenotypes in human and model organisms, shared evolutionary origin and sharing of transcription factor binding sites. Your work will shed light onto genetic design principles that underlie human brain function and will identify new candidate genes for intellectual disability by Bayesian integration of genomics data. The project combines the expertise of the Huynen group in the analysis of genomics data to predict protein function with the expertise in studying genetic disease of the group of Annette Schenck (Genetics Department Radboud University Medical Centre). This collaboration ensures direct experimental testing of interesting newly predicted candidate proteins and pathways. The position is initially for 1.3 years with possibilities for extension. Starting date: as soon as possible. Requirements: You have a PhD in Bioinformatics or in Natural Sciences with a published affinity for large-scale comparative analyses of genomics data coupled to in depth study of biological systems. Salary: starting at 40.458 – 46.695 Euro, depending on experience. For more information please contact Martijn Huynen (huynen@cmbi.ru.nl, www.cmbi.ru.nl). To apply, please e-mail a letter describing research interests and past research activities, a CV, and the names of two referees before March 7th , 2013. Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629. The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.