Postdoc in Bioinformatics of the Human Gut Microbiome
Description
The lab of Jeroen Raes (VIB, KU Leuven - Leuven, Belgium) is looking for a postdoctoral researcher in the computational analysis of microbiome data, with a particular emphasis on human-associated microbial communities in health
and disease.
Projects will focus on:
(i) bioinformatics/statistics method development for joint host and microbiota data analysis and ecology, multi-omics, diagnostic model development and clinical data integration, and/or
(ii) their application to large scale datasets generated within the Flemish Gut Flora project cohort (n>5000), in a wide range of disease cohorts as well as in international projects and/or
(iii) time series analysis of longitudinal and intervention cohorts
We look for an excellent track record in (meta-)omics data analysis and strong scientific drive. We provide a stimulating and fun environment to pursue your scientific dreams. Further info on http://www.raeslab.org
Profile
PhD in bioinformatics, computational biology, datamining, biostatistics, population and/or statistical genetics, human microbiota, numerical/microbial ecology or equivalent
Good programming skills (perl/python/ruby/java/C++ etc, SQL, R), proficiency in Unix/Linux and cluster experience
A strong track record in omics data analysis (e.g. (meta)genomics, transcriptomics, proteomics, metabolomics, epigenomics, genotyping data) is a plus
Experience in clinical datamining/machine learning, biomarker detection is a plus
We offer
VIB-KULeuven is an exciting, interdisciplinary research institute with excellent facilities and leading research groups in e.g. gastroenterology, oncology, immunology, microbiology & virology, clinical genetics/-omics, molecular
biology and translational research. The Raes lab is located on the Gasthuisberg campus of the KU Leuven (Fac. of Medicine) and has on-site robotic sample processing, high-throughput computing resources, next-gen sequencing facilities (mi/next/hi/novaSeq. PacBio,
oxford nano pore) as wel as wet-lab microbiology for validation of leads.
Interested? Check out some of our recent work!:
Falony G*, Joossens M*, Vieira-Silva S*, Wang J* et al (2016) Population-level analysis of gut microbiome variation. Science 352:560-4
Vieira-Silva S*, Falony G* et al (2016) Species-function relationships shape ecological properties of the human gut microbiome. Nature Microbiology doi:10.1038/nmicrobiol.2016.88
Vieira-Silva S, Sabino J, Valles-Colomer M, Falony G, Kathagen G, Caenepeel C, Cleynen I, van der Merwe S, Vermeire S, Raes J. (2019) Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated
microbiota alterations across PSC/IBD diagnoses. Nat Microbiol. doi: 10.1038/s41564-019-0483-9.
Hughes DA*, Bacigalupe R*, Wang J, Ruehlemann MC, Tito RY, Falony G, Joossens M, Vieira-Silva S, Henckaerts L, Rymenans L, Verspecht C, Ring S, Franke A, Wade KH, Timpson NJ*, Raes J*. (2020). Genome-wide associations of
human gut microbiome variation and implications for causal inference analyses. Nat Microbiol. doi: 10.1038/s41564-020-0743-8
Vieira-Silva S*, Falony G*, Belda E*, Nielsen T, [41 authors], Bäckhed F, Clement K* & Raes J*. (2020) Statin therapy is associated with lower prevalence of gut microbiota dysbiosis, Nature. DOI: 10.1038/s41586-020-2269-x
Vandeputte D, De Commer L, Tito RY, Kathagen G, Sabino J, Vermeire S, Faust K, Raes J. (2021) Temporal variability in quantitative human gut microbiome profiles and implications for clinical research. Nat. Commun. 12(1):6740
How to apply?
Our institute greatly values diverse standpoints and promotes an inclusive environment in which everyone is respected.