COMPUTATIONAL BIOLOGY POSITION: NGS FOR PERSONALIZED MEDICINE PROJECT OUTLINE Genetic alterations are major determinant of responses to (targeted) therapies in cancer. To gain insight into resistance mechanisms to therapy and thus better tailor treatment, genetic and response characterization for large panels of tumors are required. The Center for Personalized Cancer Treatment (CPCT) is a collaboration between the University Medical Center Utrecht, The Erasmus Medical Center Rotterdam and The Netherlands Cancer Institute Amsterdam, aimed at collecting and characterizing such cohorts. By the end of this year we will have collected and sequenced a total of 1500 tumor and normal samples. The successful candidates will work closely with biologists and clinicians to develop computational approaches that characterize the mutational landscape of these cancers with specific emphasis on the impact this landscape has on therapy response. To this end the candidate will have proprietary access to data from the Sanger Cell line panel (www.cancerRxgene.org). The goal is to integrate this database with the tumor exome and response data to bring personalized medicine a step closed to the clinic. CANDIDATE REQUIREMENTS We are seeking highly motivated Postdoc or PhD candidates with a degree in bioinformatics, computer science, mathematics or physics and with a strong cancer biology interest. Preferably applicants should have a strong documented experience in analyzing high-throughput sequencing data. In addition, we value experience in one or more of the following: sequence analysis, clinical data analysis, gene expression analysis, machine learning or applied statistics. The candidate needs to be proficient in programming languages such as Java, Perl or Python, and be comfortable with Linux systems. Fluency in spoken and written English is a strong requirement. LOCATION The project will employ the complementary expertise and tools of four groups participating in the Center for Personalized Cancer Treatment: Edwin Cuppen and Emile Voest at the University Medical Center Utrecht and Rene Bernards (Molecular Carcinogenesis) and Lodewyk Wessels (Computational Biology) at the Netherlands Cancer Institute, Amsterdam. The position is primarily embedded within the Bioinformatics and Statistics Group (Wessels) (bioinformatics.nki.nl) at the Netherlands Cancer Institute, Amsterdam. CONTACT DETAILS Please contact Dr. Lodewyk Wessels, tel. +31 20 512 7987 or e-mail: l.wessels@nki.nl. When applying please ensure you include a CV, list of publications and the names and addresses of at least two persons that can be approached as references. Also see bioinformatics.nki.nl for further information. CLOSING DATE: 1 FEBRUARY 2013