ISCB Academy is part of the International Society for Computational Biology (ISCB), which aims to provide training and workshops worldwide. We provide hands-on experience accessing and using newly developed bioinformatics tools while ensuring best practices for rigour and reproducibility. The next tutorial is under the title “Integrating gene expression and biological knowledge for drug discovery and repurposing”, which will be held on the 22nd of April at 8:00am EDT. 

Description of the Tutorial: 

Screening for potential cancer therapies using existing large datasets of drug perturbations requires expertise and resources not available to all. This is often a barrier for lab scientists to tap into these valuable resources. To address these issues, one can take advantage of prior knowledge especially those coded in standard formats such as causal biological networks (CBN). Large datasets can be converted into appropriate structures, analyzed once and the results made freely available in easy-to-use formats. In these three parts tutorial, we will give a full description of one large scale analysis of using this approach, one case study of building a network of metastasis suppressors from scratch, and a walkthrough example code to perform and adapt these tools for different use cases.

Pre-requisites:
● Knowledge of the mechanisms of transcriptional regulation
● Familiarity with high-throughput gene expression data
● Basic knowledge of R and Bioconductor
● Familiarity with Docker and Git (This is only required to execute the code on a local machine)
Register 👉 https://www.iscb.org/iscbacademy 


Dr. Venkata Satagopam
Bioinformatics Core
Luxembourg Centre For Systems Biomedicine (LCSB)
University of Luxembourg
Campus Belval, House of Biomedicine II
6, avenue du Swing
L-4367 Belvaux

T +352-466-644-6421
F +352-466-644-36421
venkata.satagopam@uni.lu  
http://lcsb.uni.lu

-----
This message is confidential and may contain privileged information. It is intended for the named recipient only. If you receive it in error please notify me and permanently delete the original message and any copies.
-----