Begin forwarded message: Chers collègues, Vous trouverez ci-dessous l'annonce de notre atelier INSERM. N'hesitez pas à la diffuser autour de vous! Merci encore pour votre participation à l'atelier. Cordialement, Christine Brun - Jérôme Reboul - Nicolas Thierry-Mieg ------------------------------------------------------ Atelier de Formation Inserm 203 Interactomique: à l'intersection de la biologie et la bioinfomatique / Interactomics: at the crossroads of biology and bioinformatics Registration dealine: January 29, 2010 Info and registration forms: http://www.rh.inserm.fr/INSERM/IntraRH/RHPublication.nsf/mDisplayMotsClefsWeb?OpenForm&arg1=17&arg2=# Phase I • Critical assessment March 30- April 1, 2010 • Saint-Raphaël • France Aims: Proteins rarely act alone: they often interact with other macromolecules in order to accomplish their functions. Protein-protein interactions are therefore critical to most biological processes. Systematic approaches for identifying them have been developped over the years, such as yeast two-hybrid or affinity purification-mass spectrometry. These methods have enabled the mapping of complex interaction networks in various model organisms, which are profoundly modifying our understanding of cellular mechanisms by providing us with an integrated view of biological processes. However, due to their complexity, such networks can be intimidating and difficult to take advantage of by hypothesis-driven experimental biologists. The main difficulties are typically methodological and technical (for example knowledge and application of bioinformatics tools), but also and more fundamentally they stem from the changes in reasoning required by the systems biology approach. Protein-protein interaction networks being a very rich but neglected source of information, the workshop will present the main strengths and challenges in producing and using this data. Indeed, a better understanding of the processes, questions and solutions proposed by labs that produce and analyze interactomics data should facilitate its general use. Audience: Researchers, physicians, post-docs, technicians, engineers and students interested in the interactome approach and the analysis of existing protein-protein interaction data, in order to benefit to their own research projects. The topics addressed will include 1) identifying protein-protein interactions: high-throughput methods, validation of results, quality assessment; 2) protein-protein interaction databases: contents, standards, direct submissions; 3) topological and functional analysis of protein-protein interaction networks: methods and tools; 4) application to biological questions: candidate genes, signaling, host-pathogen interactions, development, evolution. Confirmed speakers: Javier De Las Rivas (Salamanca, Spain), Etienne Formstecher (Paris, France), Anne-Claude Gavin (Heidelberg, Germany), Kristin Gunsalus (New York, USA), Henning Hermjakob (Hinxton, UK), Carl Herrmann (Marseille, France), Vincent Lotteau (Lyon, France), Fabio Piano (New York, USA), Evelyne Goillot (Lyon, France), Jolanta Polanowska (Marseille, France), Sylvie Ricard-Blum (Lyon, France), Benno Schwikowski (Paris, France), Jacques van Helden (Bruxelles, Belgium), Marc Vidal (Boston, USA). Phase II • Technical workshop May 2010 • Marseille Program: Participants will learn to use existing tools for extracting functional information from publicly available molecular interaction data. The course is aimed at two subgroups of participants, depending on their computer skills. The goal is to enable the participants to study their own results in the light of previously known biomolecular interactions. 15 participants will be selected among the phase I participants. Organizers: Christine Brun (TAGC, Marseille), Jérôme Reboul (CRCM, Marseille), Nicolas Thierry-Mieg (TIMC-IMAG, Grenoble)