AI Engineer / Bioinformatician – AI for Drug Discovery

Join the AI for Genome Interpretation (AI4GI) group at IGMM-CNRS, Montpellier, for a 13-month engineer position with the possibility of renewal for up to 3 additional years.

You will work at the intersection of machine learning, bioinformatics, chemoinformatics and cancer biology, in a collaboration between Raimondi and Hahne laboratories. The goal is to develop AI methods to predict drug responses in treatment-resistant CMS4 colorectal cancer and accelerate the discovery of new therapeutic molecules.

Your work will include:

• Developing novel PyTorch-based machine learning methods for drug-response prediction.
• Integrating pharmacogenomic, molecular and phenotypic data from resources such as GDSC, DepMap and CCLE.
• Developing molecular representations using chemoinformatics, molecular fingerprints and graph-based approaches.
• Building an Active Learning, experiment-in-the-loop framework that selects the most informative compounds for experimental validation.
• Applying the resulting models to the virtual screening of 78 billion compounds in the Enamine REAL chemical library.
• Working closely with experimental cancer biologists to iteratively improve the computational models.

We are looking for someone with strong Python and machine learning skills, a solid understanding of mathematics, statistics and deep learning, and familiarity with scientific computing and Linux. Experience in bioinformatics, chemoinformatics, pharmacogenomics, drug-response prediction, GNNs, Active Learning, uncertainty estimation or HPC/GPU computing is a strong advantage.

This is an opportunity to develop new AI methodologies with direct applications to drug discovery, while working in a highly interdisciplinary and international research environment at IGMM-CNRS in Montpellier.

Contract: 13 months, renewable up to 3 years
Salary: depending on experience, from around €2,521 gross/month
Benefits: 44 days annual leave/RTT, remote-working support, 75% public transport reimbursement and mobility allowance up to €300

Candidates can apply at this link https://emploi.cnrs.fr/Offres/CDD/UMR5535-SARADE-117/Default.aspx