Dear all, You may be interested in the following talk: Understanding functional disorder in proteins – examples from a stem cell regulatory network Adam Godzik In many proteins, the interplay between order and disorder is critical for their function. In the Joint Center for Structural Genomics we set out to map out and understand this balance in a group of transcription factors and regulatory complexes involved in stem cell differentiation. Many proteins in this network appear to be composed entirely of disordered regions, but upon more detailed analysis we started identifying small ordered "kernels" of order, possibly being switched on (and off) with post-translational modifications. With few of these "kernels" now confirmed by experimental structure determination we are applying these experiences to a broader range of human proteins Date: Nov, 15th VUB Room D.005, 12:00 Regards, Gipsi ---- Gipsi Lima-Mendez Bioinformatics and (Eco-)Systems Biology Faculty of Sciences and Bioengineering Sciences Vrije Universiteit Brussel VUB - MINT/BSB Pleinlaan 2 B-1050 Brussels Belgium Tel: +32-02-629 19 18 Fax: +32-02-629 19 02 gipsi.lima@vub.ac.be