Postdoctoral position in Computational structure based drug design at the CMBI, Radboud University Medical Centre

Job description

Project title: 3D-e-Chem: Integrated eScience workflow to translate biological and chemical data into structure-based protein-ligand polypharmacology prediction.

Efficient exploitation of the massive amount of modern-day life science data requires a integrative approach that only eScience technologies can provide. The 3D-e-Chem project will design a KNIME-based workflow for the integration of chemical and biological data for the prediction of polypharmacological action of drug molecules (ligands) on multiple proteins.This project will combine the strengths of the CMBI on protein structures together with the knowledge on ligand screening data and its interpretation from the department of Division of Medicinal Chemistry at VU University to develop novel chem- and bioinformatic workflows together with the Netherlands eScience Center in Amsterdam that improve the interpretation and prediction of polypharmacological effects.
 
Key words: Chem- and Bioinformatics, protein structures, polypharmacology, workflow development.

Profile candidate

• PhD in Molecular Sciences, Bioinformatics, Computer Science, Pharmacy or equivalent
• Experience in Linux, Python, Java
• Expertise in computational structure based drug design
• Experience with KNIME or Pipeline pilot are a plus
• Affinity with fundamental research related to human disease
• Good communication skills
• Ambition
• Ability to work in an interdisciplinary team

Organization

The Computational Discovery and Design group is part of the Center for Molecular and Biomolecular Informatics (www.cmbi.ru.nl) and located within the Radboud Institute for Molecular Life Sciences.

Working at Radboudumc
Radboudumc aims to be at the forefront of the development of innovative, sustainable and affordable healthcare. Our mission is 'to have a significant impact on healthcare'. We believe we can achieve that by providing excellent quality, participatory and personalized healthcare, operational excellence and by working together in sustainable networks. The starting point for this is patients and their quality of life. Throughout all this, patient care, research and education go hand in hand.

To realize our mission, we are searching for colleagues who want to take on this challenge with us; employees who are excellent in their field of expertise and give it their all by pushing boundaries and providing 'that little bit more'. At Radboudumc, you gain the confidence, receive and take responsibility to successfully make these changes. For the best patient care and the best future of healthcare.

Comments and contact information

Conditions of employment

• Employment will initially be for one year, with possible extension
• Salary starts in scale 10.4: € 3122 gross per month, up to a maximum of € 4111 gross per year, depending on experience. You will also receive an additional vacation bonus (8% per year) and end of year payments (8.3% per year).

Application
Include your curriculum vitae, description of research experience and names and addresses of 2 references in your application.

Information
Additional information about the vacancy can be obtained from dr. Tina Ritschel, Tina.Ritschel@radboudumc.nl. (This e-mail address is to be used for information purposes only. Use the ‘Apply’ button to apply for the position.)

Please apply before February 9, 2016.