From: bbclist-bounces@psb.vib-ugent.be <bbclist-bounces@psb.vib-ugent.be> On Behalf Of BeNeLux bioinformaticians forum Sent: Tuesday, 18 April 2023 13:52 To: BeNeLux bioinformaticians forum <bbclist@psb.vib-ugent.be> Subject: [BBC] PhD position on the genetic regulation of gene expression in the human brain Dear Bioinformatics colleagues, The human brain is one of the most complex organs in the body and much is still unknown about the genetic basis of psychiatric and neurological diseases. How do genetic variants associated with neurological disease change gene expression levels, and how are these changes eventually lead to disease? We are looking for a PhD student to help us get insight into these questions. We have recently finished a large scale project where we combined over 8,000 bulk RNA-seq samples in human brain, after which we determined which genetic variants change gene expression levels in different brain tissues and in different ancestry groups. We also investigated whether the association signals we identified on gene expression could also be overlapped with disease association signals. We are currently planning to further expand this dataset, to look into disease specific effects, and long-distance genetic asociations on gene expression levels. The tasks of the PhD student include creating and running bioinformatics pipelines for genotype calling, RNA-seq analysis, and eQTL analysis, and method development for large scale statitical analysis, writing papers, and presenting at (international) conferences. If you, or someone you know is interested in learning about genetics, gene regulation and complex disease in the human brain, loves to work with large datasets, and is interested in a PhD position, please apply using the link below. https://werkenbijumcg.nl/-/vacatures/phd-student-to-study-gene-expression-va... With kind regards, Harm-Jan Westra, PhD University Medical Center Groningen ________________________________ De inhoud van dit bericht is vertrouwelijk en alleen bestemd voor de geadresseerde(n). Anderen dan de geadresseerde(n) mogen geen gebruik maken van dit bericht, het niet openbaar maken of op enige wijze verspreiden of vermenigvuldigen. Het UMCG kan niet aansprakelijk gesteld worden voor een incomplete aankomst of vertraging van dit verzonden bericht. The contents of this message are confidential and only intended for the eyes of the addressee(s). Others than the addressee(s) are not allowed to use this message, to make it public or to distribute or multiply this message in any way. The UMCG cannot be held responsible for incomplete reception or delay of this transferred message.