Postdoctoral Opportunity in Genomics and Bioinformatics at IFREMER Brest (French Research Institute for the Exploration of the Sea) Marine organisms living on intertidal habitats are exposed to highly variable environments to which they must respond rapidly. Understanding the mechanisms that allow intertidal organisms to respond to environmental change is an important step to better understanding species responses to climate change. Protein kinases are a family of molecules that are involved in signal transduction and stress response, and that are often involved in detecting and modulating cellular responses to environmental change. Increasing genomic resources allow us to examine the full complement of protein kinases in organisms (the kinome), providing an unique opportunity to better understand the role of kinases in the adaptation of organisms to climate change. We are currently seeking a postdoctoral researcher to work on the kinome of the honeycomb worm (Sabellaria alveolata), a reef-building species which commonly builds bioconstructions across Europe, and has been estimated to be the largest temperate reef-builder on European shores. We have recently sequenced and annotated the S. alveolata genome, and we have further developed a bioinformatics pipeline which searches for conserved motifs in protein kinases, allowing us to retrieve the kinome for any organism (KiNext). In order to better understand local adaptation to temperature in the honeycomb worm, we have transplanted reef blocks from 5 locations in Europe (Scotland, English Channel, southern Bay of Biscay, Portugal and Morocco), exposed them to 5 temperature treatments, and sequenced transcriptomes to examine heat stress and local adaptation to heat. We are looking for a postdoc who will conduct the transcriptomic analyses, examining all genes that are differentially expressed, but with a particular focus on the protein kinases. The postdoc will use the KiNext pipeline to annotate protein kinases, and further examine kinase response to heat stress. Candidates should have experience with bioinformatics (preferably command-line). Experience with transcriptomics or ecotoxicology are desired but not mandatory. Our funding source has eligibility criteria which stipulates that the position be open to all nationalities except French (unless currently residing outside of France). Please send an email and CV to flavia.nunes@ifremer.fr by June 30, 2023. -- Flavia Nunes Laboratory of Coastal Benthic Ecology Ifremer Centre de Bretagne 1625 route de Sainte-Anne, CS 10070 29280 Plouzané, France phone: +33 2 98 22 49 27 wwz.ifremer.fr/dyneco/Lab.-Lebco