ANNOUNCEMENT The Gulbenkian Training Programme in Bioinformatics is pleased to announce that the applications for the hands-on Bioinformatics training course HPND14 Hunting for Promoters with NGS data are now OPEN. Please have a look at our website here: http://gtpb.igc.gulbenkian.pt/bicourses/HPND14/ We will have Edgar Wingender and Philip Stegmaier as instructors. Course description: This course is set-up to review the basic principles of gene regulation and the corresponding bioinformatic problems. It will start with the computational prediction of promoters and distant enhancers and will deal with the analysis of the structure of such regions by identifying binding sites for transcription factors. The most intriguing parts of genomes, still not completely understood, are the gene regulatory regions â mostly promoters and enhancers. A complete annotation of a newly sequenced genome has to address the identification of these regions in addition to the classical task of finding genes in terms of coding regions. Regulatory regions define when, where and under what conditions genes become active and, thus, are part of the fundamental function of a gene. In this course, we will overview some of the experimental methods such as next generation sequencing (NGS) techniques for genome-wide epigenetic analysis such as ChIP-seq, which have revolutionized our ways for studying the gene regulatory mechanisms. The attendees will learn about several techniques of finding promoters and enhancers and the principles on which these methods are based on. In the "hands on" exercises, several analytical tools will be introduced and the results critically evaluated to assess their reliability. Objectives: The course will consist of lectures that lay out the conceptual framework as needed and and "hands on" exercises, which will provide the practical insight on the use of the methods, gradually, in order to produce skills that can be used with a relatively high degree of independence. Participants will learn how to set-up some of the programs, and use publicly available servers for more complex analytical jobs, in an informed fashion, so that they fully understand the output generated and how its quality can be assessed. Participants will also learn the novel principles of organization of gene regulatory regions, which will help them to interpret their results of genomic and transcriptomic studies. Thank you for your continued interest P.Fernandes GTPB Coordinator -- Pedro Fernandes Instituto Gulbenkian de Ciência Apartado 14 2781-901 OEIRAS PORTUGAL Tel +351 21 4407912 http://gtpb.igc.gulbenkian.pt -- Pedro Fernandes Instituto Gulbenkian de Ciência Apartado 14 2781-901 OEIRAS PORTUGAL Tel +351 21 4407912 http://gtpb.igc.gulbenkian.pt _______________________________________________ Gtpb mailing list Gtpb@igc.gulbenkian.pt https://lists.igc.gulbenkian.pt/mailman/listinfo/gtpb