Are you an aspiring researcher with an interest in embryonic development? And are you eager to understand how individual cells in the early mammalian embryo decide their future fate using computational approaches? Then join the Radboud Institute for Molecular Life Sciences as a PhD candidate! https://www.ru.nl/en/working-at/job-opportunities/phd-candidate-in-computati... The early mammalian embryo, or epiblast, is composed of pluripotent cells that can generate all specialised cell types of the body. The epiblast cell population is heterogeneous, showing stochastic differences in transcriptome and epigenome between cells that affect their differentiation potential. In this project, you will address how a system composed of intrinsically stochastic epiblast cells can show robust and deterministic fate decisions, utilising single-cell genomic/epigenomic datasets from in vitro developing mouse gastruloids that will be generated within the consortium. You will apply state-of-the-art genetic/epigenetic computational approaches, integrative -omics, cellular trajectory analysis, agent-based modelling and other types of predictive modelling, supported by our in-house computational biology unit. Dr. Marten Postma Assistant Professor Chair Examinations Board BSc BMW/MSc BMS Member SILS Educational Committee (SEC) Programme Developer MSc BioSB JD Track coordinator Systems Biology MSc BioSB JD Member Admission Committee MSc BioSB JD zoom : https://uva-live.zoom.us/j/2612815610 Room C2.102 (SILS) Swammerdam Institute for Life Sciences (SILS) University of Amsterdam (uVA) Science Park 904 1098 XH Amsterdam The Netherlands tel : +31 20 525 6225 e-mail : M.Postma@uva.nl<mailto:M.Postma@uva.nl> website : http://www.martenpostma.nl/science/