Dear Colleagues, We are pleased to invite you to the first BioSB course of the year 2023: Constraint-based modeling: Introduction and Advanced Topics When:             13 - 17 Feb 2023 Where:            Wageningen, the Netherlands Organizers:     BioSB Research school,in collaboration with                          Wageningen University and Research (Prof. dr. Maria Suarez Diez), and                          Maastricht University (Prof. dr. Marian Breuer) Website: Constraint-based modeling: Introduction and advanced topics - Dutch Techcentre for Life Sciences (dtls.nl) <https://www.dtls.nl/courses/constraint-based-modeling-introduction-and-advanced-topics/> Registration: BioSB course Constraint based modeling 2023 - Register (aanmelder.nl) <https://www.aanmelder.nl/constraint-modeling-2023/subscribe> This course will introduce computational modeling of large (genome-scale) metabolic reaction networks through a scalable framework known as constraint-based modeling. Emphasis will be on use in both biotechnology and systems biomedicine. Main topics are fundamental contraint-based modeling methods, omics data integration, multi-scale modeling and microbial community modeling. The course combines theoretical lectures with tutorial exercises and computational exercises in Python. Target Audience Constraint-based modeling is a rapidly growing field that is being used in both fundamental and applied research and biotechnology. It sits at the intersection between quantitative modeling, bioinformatics and cellular physiology, and as such, is an example of systems biology at work. While participants would benefit from some knowledge of either quantitative modeling, bioinformatics or metabolism, this is not required. We are happy to welcome, for example, scientists working in a laboratory and wanting to learn more about building or using genome-scale metabolic models, as well as those who have used some basic COBRA methodologies, but want to know how else it can be applied to their research. More information can be found on the website. <https://www.dtls.nl/courses/constraint-based-modeling-introduction-and-advanced-topics/> We look forward to meeting you (again) in 2023! Best regards, Petra Aarnoutse @ BioSB research school <https://www.dtls.nl/biosb/> --