Dear Colleague, We would like to invite you to the twelfth edition of the ISCB Student Council Symposium on *Friday 8th July 2016 *during ISMB in *Orlando*, Florida, US. SCS is a yearly recurrent interdisciplinary symposium, linked to ISMB. Its main goal is to bring together students and young researchers from computational biology, bioinformatics, systems biology, and related fields. This symposium includes an ice-breaking event, internationally renowned keynote speakers, oral presentations, flash presentations, a poster session and the famous social event in the evening. Therefore, it provides you with the opportunity to present your research to an international audience, learn about state-of-the art research and build a worldwide scientific network. We are excited to announce our two Keynotes *John Quackenbush* and *Janet Thornton*. These experts in the fields of cancer systems biology and structural bioinformatics, respectively, will be talking about their research and experiences as leaders at the forefront of science. You can learn more about them here: http://symposium.iscbsc.org/node/187 *Abstract Submission* is currently *open* on http://symposium.iscbsc.org/ . You can also apply for one of our *travel fellowships* at the same link. Registration will open later trough the main conference website: https://www.iscb.org/ismb2016-registration Please help us spread the word by sharing our flyer (please find it attached), and using the hashtag #SCSOrlando2016 on social media. We look forward to seeing you in Orlando, Florida this summer! Bart Cuypers and Ben Siranosian SCS2016 Chair and Co-chair