Dear colleagues, Also in the new academic year the BioSB research school, Wageningen University & Reserach and Eindhoven University of Technology will organize the course: *Integrated Modeling and Optimization* 12-16 December 2022, Wageningen University Computational modelling is an absolute requisite to gain understanding of the biological mechanisms underlying patterns observed in experimental data. However, one could say that modelling is a craftsmanship, that can only be learned via intense exercising and ‘learning by doing’. In this course we offer the participants the possibility to learn and exercise the modeling process and the optimization techniques needed to fit models to data. In the course the students will learn: - to understand the common ground and the differences for applications of dynamic modeling in metabolic, regulatory, signaling, and multi-scale biological processes - how to set-up a dynamic model to represent biological networks using different interaction mechanisms - to implement, simulate and analyze dynamic network models - to understand the wide variety of problems in modelling that can be solved with optimization · - to apply different types of numerical optimization methods: global and local search methods: steepest descent, Levenberg-Marquardt, genetic algorithms, linear programming. - the combination of dynamic modeling and optimization to integrate experimental data in modelling, estimate model parameters and design experiments. - to understand how numerical optimization (linear programming) works in flux balance analysis to simulate metabolic network models. Lecturers: · Prof. Natal van Riel, Eindhoven University of Technology (course coordinator) · Dr. Aalt-Jan van Dijk, Wageningen University & Research · Prof. Jaap Molenaar, Wageningen University & Research · Dr. Hans Stigter, Wageningen University & Research · Dr. Robert Smith, Wageningen University & Research · Dr. Dragan Bosnacki, Eindhoven University of Technology Target audience: The course is aimed at PhD students with a background in bioinformatics, systems biology, computer science or a related field, and life sciences. Participants from the private sector are also welcome. A working knowledge of mathematics, especially differential equations, is recommendable, but we will distribute preparation material to be studied by students missing the required background. Furthermore, at the start we offer a math refresher to help those participants who are not (yet) involved in modelling on a daily basis. More about the last year's edition: https://www.dtls.nl/courses/integrated-modeling-and-optimization/<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.dtls.nl%2Fcourses%2Fintegrated-modeling-and-optimization%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=lMXj23wm05OtsLJrsGBzhsnIiOwAcawkkagtCNQdSR0%3D&reserved=0>  <image001.jpg><https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.dtls.nl%2Fcourses%2Fintegrated-modeling-and-optimization%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=lMXj23wm05OtsLJrsGBzhsnIiOwAcawkkagtCNQdSR0%3D&reserved=0> Integrated modeling and optimization - Dutch Techcentre for Life Sciences<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.dtls.nl%2Fcourses%2Fintegrated-modeling-and-optimization%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=lMXj23wm05OtsLJrsGBzhsnIiOwAcawkkagtCNQdSR0%3D&reserved=0> Course date 13-17 December 2021, Wageningen Location: The course will be held at: Forum Building (building nr 102), with number B0409. A Biocafe (on Thursday) will be held in “The Spot” in Building Orion (gebouw nummer 103) in the Wageningen… www.dtls.nl<https://eur02.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.dtls.nl%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Ul4n9%2FEPUxDdirFMnFK%2BpVxnVSfLrpToyiaWp%2FJG9cI%3D&reserved=0>  More details about the programme and the registration will follow soon. Please feel free to contact Dragan Bosnacki (D.Bosnacki@tue.nl) for more information. --------------------- *About BioSB* The Netherlands Bioinformatics and Systems Biology research school (BioSB) is the national platform in which the Dutch community of researchers in bioinformatics and systems biology is organized. BioSB also organizes: 1. fundamental and advanced post-graduate courses <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Feducation%2Fcourse-portfolio%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609229476%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=2zzuqQYvfLwhU6fMZDwIKvyMwD5xlzJITlRpE4WYLzw%3D&reserved=0<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Feducation%2Fcourse-portfolio%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=dVkjQj1XGJZw7b4GNFAB%2Bd%2FeJjxp3TOvX%2FqsGyR%2BgQ4%3D&reserved=0>> 2. the yearly BioSB conference <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Fconferences%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609229476%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=FGCOsjW0GYbZnwf1xzrtpBgjESPAdBSsiyomW5Ftups%3D&reserved=0<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Fconferences%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=0XQ0pwM1WywDilULilN358wPF6phGFQrGERqKLCpm3I%3D&reserved=0>> 3. hot topics meetings <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Fhottopics%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609239472%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=IEKfjekFje1m5U1ariGhzxNI%2F9QRRfXqZ6HMSQYyUVI%3D&reserved=0<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Fhottopics%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=SufnO6EqsnuKT5Ln1jxq%2BSsKSimoGT%2BV89HpofAKIco%3D&reserved=0>> The aim of the BioSB research school is to offer PhD students, postdocs and senior researchers a vibrant environment for their scientific development as well as education in bioinformatics and systems biology. In addition, BioSB acts as a parent organization for YoungCB <https://eur04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.youngcb.nl%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609239472%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=s0JGs6hegGU%2BskTBgKnAYY6fz5U%2B8cSifF9QF0IbILo%3D&reserved=0<https://eur02.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.youngcb.nl%2F&data=05%7C01%7C%7Cdb94a8b4fa6941832f8c08da6bf9c254%7Ccc7df24760ce4a0f9d75704cf60efc64%7C0%7C0%7C637941017718028636%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=xUUf%2BnrnFmY8xc4XaDOhArNQbwIjd4g6u64x28aKVBM%3D&reserved=0>>, the official Regional Student Group (RSG) of the International Society of Computational Biology (ISCB).