The Computational Biology and Bioinformatics group of the Brussels University (ULB) is seeking candidates for a postdoctoral position. *Research context*: The understanding of the biophysical mechanisms that drive single nucleobase substitutions in different regions of the human genome is one of the key questions of the post-genomic era. These mutations, whether inherited or somatic, are potentially responsible for a huge range of rare and complex diseases. The rationalization of these mechanisms is highly intricate, since base substitutions depend on the nucleotide sequence context and can be triggered by a wide range of physical, chemical or biological factors. *Objective*: In the AtOme project, we will bridge the gap between the atomic-level characterization of mutagenesis processes and the resulting phenotypic traits. More specifically, we will investigate the role of DNA charge transport in mutational and pathogenic processes using a multiscale computational approach combining quantum chemistry, machine learning and genomics. *Offer*: A full time postdoctoral position for 2 years. Flexible starting date, between now and October 2021. Possibility of extension through an FNRS postdoctoral research grant or a Marie Curie EC grant. *Required:* - PhD degree in Sciences (Bioinformatics, Bioengineer, Physics, Chemistry, Informatics). - Excellent programming skills. - Excellent publication record. - Maximum 6 years research experience after PhD. - International mobility (maximum 24 months of residence in Belgium in the last 3 years). *Desirable:* - Experience in the area of quantum chemistry, machine learning, and/or genome bioinformatics. *Contact*: Please submit: (1) a cover letter detailing your background and interest in the position, (2) a full CV and (3) two references (with name, email, address, phone number), to M. Rooman (mrooman@ulb.ac.be). *Application deadline: *June 1, 2021.