Applications are open for another Bioinformatics Training course: SMLMC14 Structural Modeling for Large Macromolecular Complexes with Joanna Kasprzak and Grzegorz Chojnowski IMPORTANT DATES for this Course Deadline for applications: May 20th 2014 < New deadline Latest notification of acceptance: May 17th 2014 Course date: June 11th - June 13th 2014 For a reference about the use of the methodology: http://dx.doi.org/10.1016/j.ymeth.2013.09.014 *Computational modeling of protein–RNA complex structures* Irina Tuszynska, Dorota Matelska, Marcin Magnus, Grzegorz Chojnowski, Joanna M. Kasprzak, Lukasz P. Kozlowski, Stanislaw Dunin-Horkawicz, Janusz M. Bujnicki Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland Bioinformatics Laboratory, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, PL-61-614 Poznan, Poland *********************************************************************** Course description One of the major challenges in structural biology is to determine the structures of macromolecular complexes and to understand their function and mechanism of action. However, structural characterisation of macromolecular assemblies is very difficult. To begin addressing this problem, we have developed PyRy3D. In a nutshell, PyRy3D employs a hybrid computational approach that incorporates spatial information from a variety of experimental methods into the modelling procedure to build low-resolution models of large macromolecular complexes. The PyRy3D model building procedure uses a Monte Carlo approach to sample the solutions-space. It uses spatial restraints to define components interacting with each other, and a simple scoring function is applied to pack them tightly into contours of the entire complex (e.g. cryoEM density maps). More details at http://gtpb.igc.gulbenkian.pt/bicourses/SMLMC14/ Thank you for your interest! Pedro Fernandes GTPB Coordinator -- Pedro Fernandes Instituto Gulbenkian de Ciência Apartado 14 2781-901 OEIRAS PORTUGAL Tel +351 21 4407912 http://gtpb.igc.gulbenkian.pt