Bioinformatics & Integrative Genomics Specialist - Manager Bioinformatics Consulting Core The VIB Center for the Biology of Disease at the University of Leuven is a vibrant and international research centre where key issues relevant to major human health challenges are tackled. Within this Center, we are seeking a highly motivated and experienced Bioinformatics & Integrative Genomics Specialist. You will collaborate with the 14 research groups within the Center and provide essential input on computational biology aspects of their research projects. In this job you will be confronted with exciting research questions in cancer and neurodegeneration; and with a broad spectrum of computational challenges and omics data sets. You will be embedded in the Laboratory of Computational Biology at the University of Leuven (Stein Aerts Lab: http://med.kuleuven.be/bioinformatics), and you will be part of an active bioinformatics community in Leuven, allowing daily interactions with colleague bioinformaticians. Your main activity will be to provide support for large-scale data analysis, and to setup and manage a Bioinformatics consulting core within the Center through which: you will collaborate with wet-lab scientists on a variety of research problems. You will deal with the data analysis part of the research project. The focus of the service will be mainly on genome bioinformatics: microarrays, RNA-Seq, ChIP-Seq, exome/genome re-sequencing, gene regulation, network biology, pathway analysis, gene prioritization, data integration, text-mining, etc. you will gradually manage a team of 1-3 Bioinformatics experts you will interact with the core facility of the VIB-BITS (http://www.bits.vib.be/), with the Genomics Core facility at the University Hospital (allowing close interaction with the next-generation sequencing instruments Illumina HiSEQ2000, Illumina MiSEQ, Roche 454, PacBio), and with other consulting units and research groups, for example for advanced biostatistics or proteomics data analysis. you will make hardware (e.g., local linux servers, high performance computing, cloud), software (e.g., a local Galaxy instance), and analysis pipelines (e.g., scripts, workflows) available to scientists; train and guide scientists to analyze their own datasets; and organize training courses and seminars. you will take your own initiatives to continuously optimize the bioinformatics flux through the Center, through the VIB and through the Group of Biomedical Sciences, for example to organize a weekly "data clinic" where small user problems can be solved. Qualifications: Master's degree in Life sciences or computational field PhD degree is strongly preferred At least five years bioinformatics experience Proven track record of high-impact publications in the field of computational biology, analysis of high-throughput data sets, data integration Solid experience with Linux, programming (e.g. Java), and database management (sql and no-sql). Solid experience with bioinformatics programming and statistics for bioinformatics, including scripting (e.g., Python), R (incl. Bioconductor), Galaxy, UCSC Genome Browser, Ensembl API, etc. Thorough understanding of molecular and developmental biology, and of disease biology (preferably cancer and/or neurological disorders). Experience with the analysis of next-generation sequence data is a plus: whole exome re-sequencing, whole-genome re-sequencing, SNP/indel calling, CNV, Structural variation; RNA-Seq, ChIP-Seq Experience with pathway analysis and cis-regulatory sequence analysis is a plus. Knowledge of machine learning and data mining is a plus. Links: The Center for the Biology of Disease The Laboratory of Computational Biology Center for Human Genetics University of Leuven Highly motivated candidates can apply by sending a motivation letter, names and contact information for three references, publication list, and CV to stein.aerts@med.kuleuven.be.