Dear colleague, It is still possible to register for the BioSB research school course: *Integrated Modeling and Optimization* 14-18 December 2020, online course Computational modelling is an absolute requisite to gain understanding of the biological mechanisms underlying patterns observed in experimental data. However, one could say that modelling is a craftsmanship, that can only be learned via intense exercising and ‘learning by doing’. In this course we offer the participants the possibility to learn and exercise the modeling process and the optimization techniques needed to fit models to data. In the course the students will learn: - to understand the common ground and the differences for applications of dynamic modeling in metabolic, regulatory, signaling, and multi-scale biological processes - how to set-up a dynamic model to represent biological networks using different interaction mechanisms - to implement, simulate and analyze dynamic network models - to understand the wide variety of problems in modelling that can be solved with optimization · - to apply different types of numerical optimization methods: global and local search methods: steepest descent, Levenberg-Marquardt, genetic algorithms, linear programming. - the combination of dynamic modeling and optimization to integrate experimental data in modelling, estimate model parameters and design experiments. - to understand how numerical optimization (linear programming) works in flux balance analysis to simulate metabolic network models. Read more <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Farchive-courses%2Fintegrated-modeling-and-optimization-2020%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609219478%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=ax36uROJL2%2BvFJ4vrFiNE99aartAL0uFdTQ1flU6Ylw%3D&reserved=0> --------------------- *About BioSB* The Netherlands Bioinformatics and Systems Biology research school (BioSB) is the national platform in which the Dutch community of researchers in bioinformatics and systems biology is organized. BioSB also organizes: 1. fundamental and advanced post-graduate courses <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Feducation%2Fcourse-portfolio%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609229476%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=2zzuqQYvfLwhU6fMZDwIKvyMwD5xlzJITlRpE4WYLzw%3D&reserved=0> 2. the yearly BioSB conference <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Fconferences%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609229476%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=FGCOsjW0GYbZnwf1xzrtpBgjESPAdBSsiyomW5Ftups%3D&reserved=0> 3. hot topics meetings <https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biosb.nl%2Fhottopics%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609239472%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=IEKfjekFje1m5U1ariGhzxNI%2F9QRRfXqZ6HMSQYyUVI%3D&reserved=0> The aim of the BioSB research school is to offer PhD students, postdocs and senior researchers a vibrant environment for their scientific development as well as education in bioinformatics and systems biology. In addition, BioSB acts as a parent organization for YoungCB <https://eur04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.youngcb.nl%2F&data=04%7C01%7Cp.d.moerland%40amsterdamumc.nl%7Cb50e6cc624ae436c8a7608d88ff446ff%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C637417626609239472%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=s0JGs6hegGU%2BskTBgKnAYY6fz5U%2B8cSifF9QF0IbILo%3D&reserved=0>, the official Regional Student Group (RSG) of the International Society of Computational Biology (ISCB).