I am seeking a highly motivated computational postdoc and staff scientist to join my group <https://www.sanger.ac.uk/group/martin-group/> at the Wellcome Sanger Institute. The group investigates the genetic basis of rare and common diseases and complex traits, primarily in populations with European and South Asian ancestry. We currently have projects in the following areas: * The role of both rare and common variants in rare developmental disorders, using data from the Deciphering Developmental Disorders<https://www.sanger.ac.uk/collaboration/deciphering-developmental-disorders-ddd/> study (N=13,000 exome-sequenced patients) and the Genomics England 100,000 Genomes project<https://www.genomicsengland.co.uk/about-genomics-england/the-100000-genomes-project/> (N~33,000 whole-genome sequenced rare disease patients), in collaboration with GeneDx (>60,000 exome sequenced patients) and with Matt Hurles’ group<https://www.sanger.ac.uk/group/hurles-group/>. We have a particular focus on the contribution of recessive variants across diverse populations (building on previous work<https://www.science.org/doi/10.1126/science.aar6731>), and on the interplay of rare and common variants. We are also beginning new projects investigating the genetic contribution to sex differences in autism and autistic traits, and on the impact of endogamy versus consanguinity on rare disease risk. * The genetics of cognitive and behavioral traits, using sequence and genotype data from UK Biobank and from two large UK birth cohorts, the Avon Longitudinal Study of Parents and Children<http://www.bristol.ac.uk/alspac/> and the Millenium Cohort Study<https://cls.ucl.ac.uk/cls-studies/millennium-cohort-study/> (N~20,000), in collaboration with with Matt Hurles’ group<https://www.sanger.ac.uk/group/hurles-group/>. This work is building on recent findings about the genetic overlap between rare neurodevelopmental disorders and cognitive/mental health traits in the general population (e.g. Niemi et al., Nature, 2018<https://www.nature.com/articles/s41586-018-0566-4>; Gardner et al., Nature, 2022<https://www.nature.com/articles/s41586-022-04549-9>). * The genetic basis of complex diseases and traits in British South Asian populations, using data from the Genes & Health project<https://www.genesandhealth.org/> (N~50,000 British Pakistani and Bangladeshi individuals with linked electronic health records). An industry consortium has recently funded exome-sequencing of the cohort to complement the existing genotype chip data. We are investigating the contribution of rare and common variants to complex disease risk, as well as the role of autozygosity. Both are three-year posts. Please get in touch if either sounds of interest. Applications will be considered on an ongoing basis and the role will close when a successful appointment has been made. https://jobs.sanger.ac.uk/vacancy/computational-postdoctoral-fellow-in-medic... https://jobs.sanger.ac.uk/vacancy/computational-senior-staff-scientist-medic... Best wishes, Hilary Martin -- The Wellcome Sanger Institute is operated by Genome Research Limited, a charity registered in England with number 1021457 and a company registered in England with number 2742969, whose registered office is 215 Euston Road, London, NW1 2BE.